Jamie L Davis

US Patent:

6342508, Jan 29, 2002

Filed:

Aug 17, 2000

Appl. No.:

09/640532

Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Derek Cecil Cole - New City NY

Assignee:

American Cyanamid Company - Madison NH

International Classification:

A61K 31165

US Classification:

514311, 514357, 514400, 514417, 514575, 546172, 546233, 5483381, 548477, 562621, 562623

Abstract:

Matrix metalloproteinases (MMps) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- from membrane bound TNF- precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. The compounds of this invention are represented by the formula where R , R , R and R are described herein.

US Patent:

6462073, Oct 8, 2002

Filed:

Jul 5, 2001

Appl. No.:

09/899641

Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Jannie Lea Baker - White Plains NY
Jeremy Ian Levin - New City NY

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 3140

US Classification:

514423, 548537, 548517, 540596, 540604, 514212, 514422

Abstract:

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- from membrane bound TNF- precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (is) and TNF- converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R and R form a heterocyclic ring and A is S, S(O), or S(O)2, and R and R are defined herein.

US Patent:

6939870, Sep 6, 2005

Filed:

Aug 29, 2003

Appl. No.:

10/652424

Inventors:

Aranapakam M. Venkatesan - Rego Park NY, US
Jamie M. Davis - Ann Arbor MI, US
Yansong Gu - Pearl River NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D417/14
C07D403/14
A61K031/53
A61K031/549
A61P025/24

US Classification:

5142232, 544 48, 544183, 544287, 514243, 51426622, 546120

Abstract:

A compound represented by the formula I: wherein A represents the following heterocycles: and Rare as defined herein, a composition containing this compound and methods for treating disorders of the serotonin-affected neurological systems utilizing such a compound or composition.

US Patent:

7148235, Dec 12, 2006

Filed:

Jun 22, 2005

Appl. No.:

11/158875

Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Jamie M. Davis - Ann Arbor MI, US
Yansong Gu - Pearl River NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 471/04
A61K 31/4375
A61P 25/24

US Classification:

514303, 546120

Abstract:

A compound represented by the formula I:.

US Patent:

7332506, Feb 19, 2008

Filed:

Aug 28, 2006

Appl. No.:

11/511150

Inventors:

Aranapakam M. Venkatesan - Rego Park NY, US
Jamie M. Davis - Ann Arbor MI, US
Yansong Gu - Pearl River NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/4375
A61P 25/24

US Classification:

514303, 546119, 546120

Abstract:

A compound represented by the formula I:.

US Patent:

61720577, Jan 9, 2001

Filed:

Feb 19, 1998

Appl. No.:

9/026371

Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Baihua Hu - Nanuet NY
Derek Cecil Cole - New City NY
Jannie Lea Baker - White Plains NY
Marcy Pamela Jacobson - Suffern NY
Matthew Robin O'Dell - Biddeford Pool ME

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A01N 4346

US Classification:

51421201

Abstract:

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-. alpha. converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-. alpha. from membrane bound TNF-. alpha. precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-. alpha. converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. The compounds of this invention are represented by the formula ##STR1## where R. sup. 1, R. sup. 2, R. sup. 3 and R. sup.

US Patent:

61977918, Mar 6, 2001

Filed:

Aug 26, 1998

Appl. No.:

9/140504

Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Jannie Lea Baker - White Plains NY
Jeremy Ian Levin - New City NY

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

A61K 31445
C07D21154

US Classification:

514327

Abstract:

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-. alpha. converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-. alpha. from membrane bound TNF-. alpha. precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-. alpha. converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula ##STR1## wherein R. sup. 2 and R. sup. 3 form a heterocyclic ring and A is S, S(O), or S(O). sub. 2, and R. sup. 1 and R. sup.