Charles A. Dvorak - Palo Alto CA Douglas L. Wren - Palo Alto CA Lawrence E. Fisher - Mountain View CA Steven D. Axt - San Jose CA Eric R. Humphreys - San Bruno CA Humberto B. Arzeno - Cupertino CA Colin C. Beard - Palo Alto CA Sam Linh Nguyen - Denver CO Yeun-Kwei Han - Louisville CO Christopher R. Roberts - Berthoud CO Jan P. Lund - Boulder CO Paul R. Fatheree - San Francisco CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07D47318
US Classification:
544276
Process For Preparing A 2-(2-Amino-1,6-Dihydro-6-Oxo-Purin-9-Yl)Methoxy-1,3-Propanediol Derivative
Charles A. Dvorak - Palo Alto CA Douglas L. Wren - Palo Alto CA Lawrence E. Fisher - Mountain View CA Steven D. Axt - San Jose CA Eric R. Humphreys - San Bruno CA Humberto B. Arzeno - Cupertino CA Colin C. Beard - Palo Alto CA Sam Linh Nguyen - Denver CO Yeun-Kwei Han - Louisville CO Christopher R. Roberts - Berthoud CO Jan P. Lund - Boulder CO Paul R. Fatheree - San Francisco CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07C 67743 C07C 6702
US Classification:
560106
Abstract:
Process for preparing intermediates of formula (III) ##STR1## wherein Y. sup. 1 is acyloxy, wherein acyl is of the formula R--C(O)--, wherein R is alkyl of 1-6 carbon atoms, Y. sup. 2 is aralkyloxy, and Z is benzoyloxy or acyloxy, wherein acyl is as defined above. Intermediates of formula (III) are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
Process For Preparing A 2-(2-Amino-1,6-Dihydro-6-Oxo-Purin-9-Yl)Methoxy-1,3-Propanediol Derivative
Charles A. Dvorak - Palo Alto CA Douglas L. Wren - Palo Alto CA Lawrence E. Fisher - Mountain View CA Steven D. Axt - San Jose CA Eric R. Humphreys - San Bruno CA Humberto B. Arzeno - Cupertino CA Colin C. Beard - Palo Alto CA Sam Linh Nguyen - Denver CO Yeun-Kwei Han - Louisville CO Christopher R. Roberts - Berthoud CO Jan P. Lund - Boulder CO Paul R. Fatheree - San Francisco CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07C 67743 C07C 6702
US Classification:
560106
Abstract:
Intermediates of Formula (III) ##STR1## wherein Y. sup. 1 is acyloxy, wherein acyl is of the formula R--C(O)--, wherein R is alkyl of 1-6 carbon atoms, Y. sup. 2 is aralkyloxy, and Z is benzoyloxy or acyloxy, wherein acyl is as defined above. Intermediates of formula (III) are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
Process For Preparing A 2-(2-Amino-1,6-Dihydro-6-Oxo-Purin-9-Yl) Methoxy-1,3-Propanediol Derivative
Charles A. Dvorak - Palo Alto CA Douglas L. Wren - Palo Alto CA Lawrence E. Fisher - Mountain View CA Steven D. Axt - San Jose CA Eric R. Humphreys - San Bruno CA Humberto B. Arzeno - Cupertino CA Colin C. Beard - Palo Alto CA Sam Linh Nguyen - Denver CO Yeun-Kwei Han - Louisville CO Christopher R. Roberts - Berthoud CO Jan P. Lund - Boulder CO Paul R. Fatheree - San Francisco CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07D47318
US Classification:
544276
Abstract:
Process and novel intermediates for preparing the L-mono-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process and intermediates provide for reduced impurities in the mono-valine ester end-product and lower overall production costs. The process involves the condensation of a silylated guanine compound with a substituted glycerol derivative and esterification of this product with an L-valine derivative. These mono-valine products are of value as antiviral agents with improved absorption.
states. The Rays of Hope team led by Captain Geri Wolf introduced the Car Crush, in which sledge hammers were used to beat on a car. Jan Lund was named a 2013 Hero of Hope by the American Cancer Society. The Cancer Survivors Supper held at Shiloh Christian School served more than 500 survivors.
"The lighting of the luminaria bags is a way to honor survivors and remember those lost to cancer," said Jan Lund, the Relay co-chair. "It is the portion of the Relay for Life experience when we reflect on our own or loved one's cancer experience and to find hope that tomorrow holds the promise of a
SingaporeThe Boss at Asia Adviser Working inside the mediabusiness for 35 years as sportswriter, foreign correspondent (New York, Tokyo, New Delhi, London), editor at largest circulated... Working inside the mediabusiness for 35 years as sportswriter, foreign correspondent (New York, Tokyo, New Delhi, London), editor at largest circulated newspaper in Denmark (Jyllands-Posten), been publishing magazines and making speeches about various subjects concerning Asia - often as a follow up...