Jane R Costa

US Patent:

20100056441, Mar 4, 2010

Filed:

Mar 19, 2007

Appl. No.:

12/282113

Inventors:

Robert H. Costa - Oak Park IL, US
Jane B. Costa - Oak Park IL, US
I-Ching Wang - Chicago IL, US

International Classification:

A61K 38/17
A61K 38/10
A61K 38/08

US Classification:

514 12, 514 13, 514 15

Abstract:

The invention provides methods for inhibiting angiogenesis in an animal in need thereof. The invention also pro-vides methods for preventing tumor growth and metastasis in an animal comprising inhibiting FoxM1B activity.

US Patent:

20090075376, Mar 19, 2009

Filed:

Jan 6, 2005

Appl. No.:

11/571030

Inventors:

Robert Cossta - Oak Park IL, US
Jane B. Costa - Oak Park IL, US
I-Ching Wang - Cincinnati OH, US

Assignee:

The Board of Trustees of the University of Illnois - Urbana IL

International Classification:

C12N 5/06
C07H 21/02
C12N 15/63
A61K 31/7105

US Classification:

435375, 536 245, 4353201, 514 44

Abstract:

The invention provides methods for inhibiting tumor cell proliferation by inhibiting Fox M1B (also called Fox M1) activity in a tumor cell. The invention also provides FoxM1B siRNA molecules and pharmaceutical compositions comprising FoxM1B siRNA molecules, wherein the siRNA molecules can inhibit FoxM1B activity and can inhibit proliferation of tumor cells. The invention further provides methods for preventing tumor growth, progression or both in an animal comprising inhibiting FoxM1B activity using siRNA molecules or pharmaceutical compositions comprising FoxM1B siRNA molecules.