Jane J Kelly

US Patent:

7829578, Nov 9, 2010

Filed:

Dec 5, 2006

Appl. No.:

11/633509

Inventors:

Michael K. Riscoe - Tualatin OR, US
Rolf W. Winter - Portland OR, US
Jane X. Kelly - Lake Oswego OR, US
Martin J. Smilkstein - Portland OR, US
David J. Hinrichs - Lake Oswego OR, US

Assignee:

Oregon Health & Science University - Portland OR
U.S. Department of Veterans Affairs - Washington DC

International Classification:

C07D 215/38
A61K 31/04

US Classification:

514312, 546153, 546159

Abstract:

Aromatic ketones having an extended fluoro-alkyl or fluoro-alkoxy moiety are disclosed. In particular aspects, the compounds comprise substituted 9-acridone, 9-xanthone, 4(1H)-quinolone, 4(1H) pyridone, 1,4-naphthoquinone, 9,10-anthraquinone derivatives. These preparations possess potent pharmacological activity for inhibiting malaria and mosquito-borne () diseases. The haloalkyl/alkoxy aromatic compounds possess significant pharmacological activity, with ICvalues in the nanomolar and sub-nanomolar range, and reduced toxicity against host derived cells and tissues. Methods of using the fluoro-alkyl/alkoxy aromatic compounds in the treatment of malaria and other human and animal diseases are also disclosed. Agricultural uses of the fluoro-alkyl/alkoxy aromatic compounds, such as in control of fungal diseases and in the production of important commercial crops (apples, etc. ), are also presented.

US Patent:

8592447, Nov 26, 2013

Filed:

Nov 13, 2007

Appl. No.:

12/312503

Inventors:

Michael K. Riscoe - Tualatin OR, US
Rolf Winter - Portland OR, US
Jane X. Kelly - Lake Oswego OR, US
David J. Hinrichs - Lake Oswego OR, US
Martin J. Smilkstein - Portland OR, US

Assignee:

Oregon Health & Science University - Portland OR
The United States of America, as represented by the Department of Veterans Affairs - Washington DC

International Classification:

A61K 31/44
C07D 219/04

US Classification:

514297, 546103

Abstract:

A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.

US Patent:

8598354, Dec 3, 2013

Filed:

Jun 3, 2011

Appl. No.:

13/153350

Inventors:

Michael K. Riscoe - Tualatin OR, US
Jane X. Kelly - Lake Oswego OR, US
Rolf W. Winter - Portland OR, US
David J. Hinrichs - Lake Oswego OR, US
Martin J. Smilkstein - Portland OR, US
Aaron Nilsen - Portland OR, US
Jeremy Burrows - Eysins, CH
Dennis Kyle - Lithia FL, US
Roman Manetsch - Tampa FL, US
Richard M. Cross - Brandon FL, US
Andrii Monastyrskyi - Tampa FL, US
David L. Flanigan - Riverview FL, US

Assignee:

University of South Florida - Tampa FL
Medicines for Malaria Venture - Geneva

International Classification:

C07D 215/233
A61K 31/47
A61P 31/00
A61P 33/00
A61P 33/02
A61P 33/06

US Classification:

546153, 514312

Abstract:

Compounds of formula I:.

US Patent:

20120010237, Jan 12, 2012

Filed:

Jun 3, 2011

Appl. No.:

13/153347

Inventors:

Michael K. Riscoe - Tualatin OR, US
Jane X. Kelly - Lake Oswego OR, US
Rolf W. Winter - Portland OR, US
David J. Hinrichs - Sherwood OR, US
Martin J. Smilkstein - Portland OR, US
Aaron Nilsen - Portland OR, US

International Classification:

A61K 31/47
A61P 33/00

US Classification:

514312

Abstract:

A method for inhibiting a parasitic or infectious disease in a subject, wherein the parasitic or infectious disease is selected from one caused by sp., sp., sp. or , the method comprising administering to the subject a therapeutically effective amount of a compound of formula I:

US Patent:

20200369616, Nov 26, 2020

Filed:

May 26, 2020

Appl. No.:

16/883974

Inventors:

- Portland OR, US
- Washington DC, US
Rolf W. Winter - Portland OR, US
Aaron C. Nilsen - Portland OR, US
Stone S. Doggett - Portland OR, US
Martin Smilkstein - Portland OR, US
Yuexin Li - Portland OR, US
Jane Kelly - Portland OR, US
Rozalia Dodean - Portland OR, US

International Classification:

C07D 215/22
A61P 33/06

Abstract:

Provided are compounds of Formula (I):wherein: X is selected from the group of F and Cl; Y is selected from the group of —CH—, —CH—CH—, and —CH(CH)—; Ris selected from cycloalkyl, heterocyclyl, aromatic, heteroaromatic, and linear and branched alkyl, alkenyl, and alkynyl chains.

US Patent:

20200157053, May 21, 2020

Filed:

Jan 22, 2020

Appl. No.:

16/749170

Inventors:

- Portland OR, US
- Washington DC, US
Allison Stickles - Portland OR, US
Galen Miley - Portland OR, US
Rolf Winter - Portland OR, US
Sovitj Pou - PORTLAND OR, US
Yuexin Li - Portland OR, US
Jane Xu Kelly - Portland OR, US
Isaac Forquer - Portland OR, US
J. Stone Doggett - Portland OR, US
Igor Bruzual - Portland OR, US
Lisa Frueh - Portland OR, US
Rozalia Dodean - Portland OR, US
Martin Smilkstein - Portland OR, US
Holland Alday - Portland OR, US
Dennis Koop - Portland OR, US
Lisa Bleyle - Portland OR, US

International Classification:

C07D 215/22
C07D 409/12
C07D 405/12

Abstract:

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

US Patent:

20190389802, Dec 26, 2019

Filed:

Aug 23, 2018

Appl. No.:

16/110956

Inventors:

- Portland OR, US
- WASHINGTON DC, US
Allison Stickles - Portland OR, US
Galen Miley - Portland OR, US
Rolf Winter - Portland OR, US
Sovitj Pou - PORTLAND OR, US
Yuexin Li - Portland OR, US
Jane Xu Kelly - Portland OR, US
Isaac Forquer - Portland OR, US
J. Stone Doggett - Portland OR, US
Igor Bruzual - Portland OR, US
Lisa Frueh - Portland OR, US
Rozalia Dodean - Portland OR, US
Martin Smilkstein - Portland OR, US
Holland Alday - Portland OR, US
Dennis Koop - Portland OR, US
Lisa Bleyle - Portland OR, US

International Classification:

C07D 215/22
C07D 409/12
C07D 405/12

Abstract:

Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject.

US Patent:

20180009760, Jan 11, 2018

Filed:

Feb 23, 2017

Appl. No.:

15/440458

Inventors:

- Portland OR, US
- Washington DC, US
Sovitj Pou - Beaverton OR, US
David J. Hinrichs - Sherwood OR, US
Jane Xu Kelly - Lake Oswego OR, US
Yuexin Li - Vancouver WA, US
Aaron Nilsen - Portland OR, US

Assignee:

Oregon Health & Science University - Portland OR
The United States Government as Represented by the Department of Veterans Affairs - Washington DC

International Classification:

C07D 215/46
C07D 401/12
A61K 31/47

Abstract:

Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.