The present disclosure relates to N-benzyl pyrrole compounds of formula (I) useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders.
Joel Moore - Lexington MA, US James Jia - Somerville MA, US Takashi Nakai - Newton MA, US Charles Kim - Cambridge MA, US Thomas Wai-Ho Lee - Lexington MA, US Jane Yang - Andover MA, US
Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
Colleen Hudson - Malden MA, US Timothy C. Barden - Salem MA, US James Jia - Somerville MA, US Ara Mermerian - Melrose MA, US Bo Peng - Arlington MA, US Jane Yang - Boxborough MA, US Xiang Y. Yu - Acton MA, US Kevin Sprott - Needham MA, US Angelika Fretzen - Somerville MA, US
The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.
Medicine Doctors
Dr. Jane M Yang, Boston MA - MD (Doctor of Medicine)
UCLA Medical GroupUCLA Gonda Goldschmeid Vascular Center 200 Ucla Medical Plz, Los Angeles, CA 90095 3102066294 (phone), 3107949603 (fax)
Education:
Medical School Columbia University College of Physicians and Surgeons Graduated: 2006
Languages:
English Spanish
Description:
Dr. Yang graduated from the Columbia University College of Physicians and Surgeons in 2006. She works in Los Angeles, CA and specializes in Vascular Surgery. Dr. Yang is affiliated with Ronald Reagan UCLA Medical Center and Santa Monica UCLA Medical Center.
Jane Yang (2000-2003), Matt Parrish (2004-2007), Davis Park (2000-2003), Mary Ann Horcher (1978-1981), Ray Maiello (1993-1996), Michael Homison (2003-2006)