Janet L Brandsma

US Patent:

20130137086, May 30, 2013

Filed:

May 9, 2011

Appl. No.:

13/696546

Inventors:

Janet L. Brandsma - Guilford CT, US
Paul M. Lizardi - Wallingford CT, US

Assignee:

YALE UNIVERSITY - New Haven CT

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

Disclosed are methods, compositions, devices, and systems for assessing cancer potential, state, stage, risk of progression, prognosis, etc. of a subject based on determining the methylation state of human papillomavirus (HPV) in a sample from the subject. The cancers assessed generally can be cancer associated with or caused by HPV. For example, cervical cancer, vulvar cancer, penile cancer, anal cancer, and head and neck cancer can be associated with HPV. It has been discovered that certain patterns, profiles, and sets of methylation of HPV genomes are correlated with different cancer potential, state, stage, risk of progression, prognosis, etc.

US Patent:

58116320, Sep 22, 1998

Filed:

Sep 26, 1994

Appl. No.:

8/311803

Inventors:

Janet L. Brandsma - New Haven CT

International Classification:

C12N 500
C12N 1500
A61K 4800

US Classification:

800 2

Abstract:

A method for producing a mammalian model for papillomavirus infection by engrafting a portion of human skin onto a transplant-tolerant non-human mammal, inoculating the engrafted human skin with a papillomavirus genomic DNA such that a papillomavirus infection develops in the engrafted human skin or human skin cells. The non-human mammals are then used to identify compounds and therapies effective against papillomavirus infections.