Janet H Davis

US Patent:

20060153894, Jul 13, 2006

Filed:

Jun 29, 2005

Appl. No.:

11/170410

Inventors:

Ragae Ghabrial - Helmetta NJ, US
Ramie Fung - Flemington NJ, US
Alireza Rezania - Hillsborough NJ, US
Janet Davis - Branchburg NJ, US

International Classification:

A61K 38/18
A61F 2/00

US Classification:

424426000, 514002000

Abstract:

This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

US Patent:

20070202145, Aug 30, 2007

Filed:

Dec 31, 2003

Appl. No.:

10/749192

Inventors:

Ragae Ghabrial - Helmetta NJ, US
Janet Davis - Branchburg NJ, US

International Classification:

A61F 2/02
A61K 38/18
A61K 38/22
A61K 35/12
A61K 39/395
A61K 31/203

US Classification:

424423000, 424093700, 514012000, 514559000, 424130100

Abstract:

This idea represents a method for incorporation of a therapeutic molecule, preferably a protein or a growth factor, into a biodegradable scaffold, specifically one that is made of a foam nonwoven composite. The process utilizes a solvent preferably tertiary butanol to facilitate the infiltration of the particles of the therapeutic agent into the porous matrix of the scaffold. In the case of small molecules, such as a p38 kinase inhibitor, the drug is dissolved directly in sterile filtered t-butanol and a given amount is pipetted aseptically onto the pre-sterilized scaffold. The solution is readily adsorbed into the polymer matrix. The solution is readily frozen to allow minimal interaction with the polymer scaffold thereby protecting the scaffold's internal matrix. The solvent is then aseptically removed by lyophilization.