Janet Elaine Davis

US Patent:

20050106147, May 19, 2005

Filed:

Aug 27, 2004

Appl. No.:

10/928291

Inventors:

Robert Jordan - Thornton PA, US
Susan Tam - Boothwyn PA, US
Janet Davis - Branchburg NJ, US
Mark Zimmerman - East Brunswick NJ, US
Gang Xu - Belle Meade NJ, US
Norma Kenyon - Miami FL, US

International Classification:

A61K039/395

US Classification:

424145100

Abstract:

The present invention is directed to a method of using function blocking tissue factor antibodies to enhance graft survival in mammals. Function blocking antibodies having the effect of blocking activated tissue factor (TF), TF and its ligand FVII as either the inactive TF:FVII or active TF:FVIIa complex, or block the formation of the TF:FVIIa:FX ternary complex are useful in the method. These properties provide a therapy that has directed action towards thrombotic events involving tissue-plasma interactions but does not prevent the intrinsic pathway for coagulation. Activated TF arises on cells, tissues, and organs during or after transplantation and is a major cause of graft loss.

US Patent:

20200360270, Nov 19, 2020

Filed:

Aug 5, 2020

Appl. No.:

16/985350

Inventors:

- St. Paul MN, US
Bryan L. STEELMAN - St. Paul MN, US
Thomas J. WEBSTER - Barrington RI, US
Janet E. Davis - Greenville NC, US

International Classification:

A61K 9/00
A61F 2/02
A61K 47/02
A61K 31/337
A61K 31/397
A61K 31/436
A61K 31/65
A61K 31/7036
A61K 35/28
A61K 38/14
A61K 38/18
A61K 38/22
A61K 39/395
A61M 39/02

Abstract:

The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.