Janet Y Davis

US Patent:

8623648, Jan 7, 2014

Filed:

Apr 24, 2008

Appl. No.:

12/108852

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US

Assignee:

Janssen Biotech, Inc. - Horsham PA

International Classification:

A01N 61/00
C12N 5/00
C12N 5/02
C12N 5/08

US Classification:

435377, 435325, 435366, 514 1

Abstract:

The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.

US Patent:

20100015711, Jan 21, 2010

Filed:

Jun 30, 2009

Appl. No.:

12/494789

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Christine Parmenter - Skillman NJ, US
Pascal Ghislain André Bonnet - Beerse, BE

International Classification:

C12N 5/00

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20110091971, Apr 21, 2011

Filed:

Jun 29, 2009

Appl. No.:

12/493741

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Gopalan Raghunathan - San Diego CA, US
Michael Joseph Hunter - San Diego CA, US
Jose Pardinas - San Diego CA, US
Judith Ann Connor - San Diego CA, US
Ronald Vernon Swanson - San Diego CA, US
Ellen Chi - San Diego CA, US

International Classification:

C12N 5/0735
C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20110151561, Jun 23, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970365

Inventors:

JANET DAVIS - SKILLMAN NJ, US
CHRISTINE PARMENTER - SKILLMAN NJ, US
KEVIN DITOLVO - SKILLMAN NJ, US

International Classification:

C12N 5/071

US Classification:

435377

Abstract:

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage.

US Patent:

20120190111, Jul 26, 2012

Filed:

Mar 29, 2012

Appl. No.:

13/434370

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Christine Parmenter - Skillman NJ, US
Pascal Ghislain André Bonnet - Beerse, BE

International Classification:

C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20120190112, Jul 26, 2012

Filed:

Mar 29, 2012

Appl. No.:

13/434392

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Christine Parmenter - Skillman NJ, US
Pascal Ghislain André Bonnet - Beerse, BE

International Classification:

C12N 5/07

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20120196365, Aug 2, 2012

Filed:

Mar 29, 2012

Appl. No.:

13/434409

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Christine Parmenter - Skillman NJ, US
Pascal Ghislain Andrè Bonnet - Beerse, BE

International Classification:

C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.