Janet D Robishaw

US Patent:

20060154285, Jul 13, 2006

Filed:

Dec 28, 2005

Appl. No.:

11/320422

Inventors:

Janet Robishaw - Catawissa PA, US
Tinchung Leung - Danville PA, US

International Classification:

C12Q 1/68
C07H 21/04
C12P 21/06
A61K 48/00
C07K 14/82
A61K 39/395
C07K 16/30

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 530388800, 514044000, 536023500

Abstract:

The invention provides sequences of the zebrafish heterotrimeric G-protein gamma 2 subunit (GNG2). The invention also provides methods of inhibiting and promoting GNG2-dependent angiogenesis in vertebrates, particular mammals, including humans, for the treatment of angiogenesis-related diseases. The invention also provides methods of identifying compounds that promote or inhibit angiogenesis through their interaction with GNG2. The invention further provides methods of modulating angiogenesis through the modulation of both GNG2 and VEGF.

US Patent:

20020106678, Aug 8, 2002

Filed:

Oct 22, 2001

Appl. No.:

09/982809

Inventors:

Janet Robishaw - Catawissa PA, US
Charles Kunsch - Norcross GA, US

International Classification:

C12Q001/68
G01N033/53
G01N033/567
C07K014/705

US Classification:

435/006000, 435/007100, 530/350000, 435/069100, 435/325000, 435/320100

Abstract:

Nucleic acid molecules encoding human , , , , , and subunits are provided. Subunit polypeptides are also provided. In addition, method of detecting mutated forms of human subunit and altered levels of human subunit are provided. Methods of identifying antagonists and agonists of the interaction of a ligand with its receptor are also provided.