Peter Ronald Young - Lawrenceville NJ Ian E. James - Ardmore PA Janice R. Connor - Fort Washington PA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12N 1524 C12N 1500
US Classification:
435 6952
Abstract:
IL-1 delta polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IL-1 delta peptides are polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e. g. inflammatory bowel disease, psoriasis), transplant rejection, graft versus host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, bone diseases (e. g. osteoporosis), cancer (e. g. lymphoproliferative disorders), atherosclerosis, and Alzheimer's disease, among others, and diagnostic assays for such conditions.