Jared M Lewis

US Patent:

20040063756, Apr 1, 2004

Filed:

Jun 12, 2003

Appl. No.:

10/460139

Inventors:

Christine Collins - Skokie IL, US
Ju Gao - Gurnee IL, US
Philip Kym - Grayslake IL, US
Jared Lewis - Oakland CA, US
Andrew Souers - Evanston IL, US
Anil Vasudevan - Gurnee IL, US
Dariusz Wodka - Waukegan IL, US

International Classification:

A61K031/4709
A61K031/47
C07D215/38

US Classification:

514/313000, 546/159000

Abstract:

The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

US Patent:

20190211367, Jul 11, 2019

Filed:

Jan 11, 2019

Appl. No.:

16/246246

Inventors:

- Pasadena CA, US
Eric M. Burstad - Durham NC, US
Frances H. Arnold - La Canada CA, US
Zhan Wang - San Jose CA, US
Jared C. Lewis - Chicago IL, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12P 13/02
C12N 9/02
C12P 7/62

Abstract:

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

US Patent:

20170247725, Aug 31, 2017

Filed:

Sep 28, 2016

Appl. No.:

15/278561

Inventors:

- Pasadena CA, US
Eric M. Brustad - Durham NC, US
Frances H. Arnold - La Canada CA, US
Zhan Wang - San Jose CA, US
Jared C. Lewis - Chicago IL, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12P 13/02
C12N 9/02
C12P 7/62

Abstract:

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

US Patent:

20160002682, Jan 7, 2016

Filed:

Feb 18, 2015

Appl. No.:

14/625449

Inventors:

- Pasadena CA, US
Eric M. Brustad - Durham NC, US
Frances H. Arnold - La Canada CA, US
Zhan Wang - San Jose CA, US
Jared C. Lewis - Chicago IL, US

International Classification:

C12P 13/02
C12P 7/62

Abstract:

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

US Patent:

20150267232, Sep 24, 2015

Filed:

Apr 1, 2015

Appl. No.:

14/676744

Inventors:

- Pasadena CA, US
Frances H. Arnold - La Canada CA, US
Jared C. Lewis - Chicago IL, US
Zhan Wang - San Jose CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12P 13/00
C07C 311/16
C12P 17/10
C07D 275/06
C07C 229/18
C12N 9/02
C07C 311/29
C12P 17/14

Abstract:

This invention relates to the use of heme-containing enzymes to catalyze carbene and nitrene insertion and transfer reactions with greater selectivity, mild reaction conditions, and convenient production.

US Patent:

20140242647, Aug 28, 2014

Filed:

Feb 20, 2014

Appl. No.:

14/185861

Inventors:

- Pasadena CA, US
Eric M. Brustad - Durham NC, US
Frances H. Arnold - La Canada CA, US
Zhan Wang - San Jose CA, US
Jared C. Lewis - Chicago IL, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12P 13/02
C12P 7/62

US Classification:

435129, 435189, 435135

Abstract:

The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.