Jason Preston Brewer

US Patent:

20110288069, Nov 24, 2011

Filed:

Apr 22, 2011

Appl. No.:

13/092332

Inventors:

William H. Bunnelle - Mundelein IL, US
Marc Scanio - Lindenhurst IL, US
Jason T. Brewer - Zion IL, US
Ying Wang - Lake Villa IL, US

Assignee:

ABBOTT LABORATORIES - Abbott Park IL

International Classification:

A61K 31/5513
A61P 25/00
A61K 31/551
C07D 487/04
C07D 487/14

US Classification:

51421021, 540559, 540497, 514220

Abstract:

The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I)wherein R, R, R, R, X, Y, Y, and Yare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

US Patent:

20190290632, Sep 26, 2019

Filed:

Feb 14, 2019

Appl. No.:

16/276144

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

A61K 31/454
C07D 405/14
C07D 403/10
A61K 31/4192
A61K 31/4178
A61K 31/4025
C07D 403/12
C07D 403/14
C07D 207/273
C07D 205/04
C07D 401/12
C07D 233/42
A61K 31/397

Abstract:

The present invention relates to aminotetraline and aminoindane derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.

US Patent:

20190290645, Sep 26, 2019

Filed:

Feb 14, 2019

Appl. No.:

16/275938

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

A61K 31/501
A61K 31/4433
A61K 31/4192
A61K 31/4178
C07D 405/04
A61K 31/397
C07D 311/58
C07D 405/14
A61K 31/4155

Abstract:

The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

US Patent:

20170172993, Jun 22, 2017

Filed:

Mar 3, 2017

Appl. No.:

15/449615

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

A61K 31/454
A61K 31/4192
A61K 31/4025
A61K 31/4178
A61K 31/397

Abstract:

The present invention relates to aminotetraline and aminoindane derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.

US Patent:

20170173009, Jun 22, 2017

Filed:

Mar 3, 2017

Appl. No.:

15/449565

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

A61K 31/501
A61K 31/4433
A61K 31/4155
A61K 31/4192
A61K 31/4178
A61K 31/397

Abstract:

The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

US Patent:

20150111867, Apr 23, 2015

Filed:

Oct 17, 2014

Appl. No.:

14/517034

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

C07D 405/14
C07D 405/04

US Classification:

5142102, 5483114, 548953, 548256, 5462827, 544238, 51421019, 5483644

Abstract:

The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I)or a physiologically tolerated salt thereofThe invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquin oline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.

US Patent:

20150111875, Apr 23, 2015

Filed:

Oct 17, 2014

Appl. No.:

14/517205

Inventors:

- Wiesbaden, DE
- North Chicago IL, US
Udo Lange - Ludwigshafen, DE
Ying Wang - Libertyville IL, US
Jason Brewer - Zion IL, US
Anil Vasudevan - Union Grove WI, US
Yanbin Lao - North Chicago IL, US
Charles Hutchins - Green Oaks IL, US
Hongyu Zhao - Libertyville IL, US

International Classification:

C07D 403/14
C07D 405/14
C07D 403/10

US Classification:

51421021, 5483147, 5142102, 548953, 548524, 548255

Abstract:

The present invention relates to aminotetraline and aminoindane derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminotetraline and aminoindane derivatives, and the use of such aminotetraline and aminoindane derivatives for therapeutic purposes. The aminotetraline and aminoindane derivatives are GlyT1 inhibitors.

US Patent:

20140275086, Sep 18, 2014

Filed:

Mar 17, 2014

Appl. No.:

14/215533

Inventors:

- North Chicago IL, US
- Wiesbaden, DE
Udo Lange - Ludwigshafen, DE
Ying X. Wang - Libertyville IL, US
Hongyu H. Zhao - Libertyville IL, US
Jason T. Brewer - Zion IL, US
Irini Zanze - Libertyville IL, US
Justin Dietrich - Abbott Park IL, US
Anil Vasudevan - Union Grove WI, US
Stevan W. Djuric - Libertyville IL, US
Yanbin Lao - Abbott Park IL, US
Charles W. Hutchins - Green Oaks IL, US

International Classification:

C07D 207/09
C07D 401/12
C07D 207/48
C07D 401/14
C07D 403/14
C07D 487/04
C07D 487/10
C07D 417/14
C07D 409/14
C07D 495/04
C07D 471/04
C07D 403/12
C07D 405/14

US Classification:

5142358, 5483147, 514402, 548567, 514428, 5483641, 514407, 5462764, 514343, 548542, 514424, 5462744, 514341, 544331, 514275, 544238, 51425205, 544122

Abstract:

The present invention relates to pyrrolidine derivatives of the formula (I),or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.