Jason M Calhoun

US Patent:

20050148553, Jul 7, 2005

Filed:

Sep 3, 2004

Appl. No.:

10/933455

Inventors:

Raymond Testa - Cedar Grove NJ, US
Jason Calhoun - Columbia MO, US
Jon Mader - Dickinson TX, US
Donna Mader - Mineola TX, US

International Classification:

A61K031/65
A61K031/4745

US Classification:

514154000, 514291000

Abstract:

The present invention is directed to a method for treating bone or bone marrow infections, joint infection or infection of the tissues surrounding the joint by administration of the antibiotic tigecycline alone or in combination with a rifamycin antibiotic. In a preferred embodiment the bone or bone marrow infection causes osteomyelitis. In another embodiment the joint infection or infection of the tissues surrounding the joint causes septic arthritis. The invention is also directed to manufacture of a medicament for treatment of bone and/or bone marrow infections, or joint infections and/or infections in tissues surrounding the joint with tigecycline alone or in combination with rifampin.