Jason J Chen

US Patent:

6809077, Oct 26, 2004

Filed:

Oct 12, 2001

Appl. No.:

09/976219

Inventors:

Yat Sun Or - Cambridge MA
Tsvetelina Ivanova Lazarova - Brookline MA
Blake Christopher Hamann - Cambridge MA
Jason Shih-Hao Chen - Claremont CA

Assignee:

Enanta Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 3813

US Classification:

514 11, 514 2, 514 9, 514828, 530317, 530318, 530402, 4242781

Abstract:

The present invention relates to a cyclosporin analog of the following formula (I) or a pro-drug or pharmaceutically acceptable salt thereof: In particular, residue A maybe represented by either formula A1 or A2 as illustrated below: where X and Y are defined herein. In a second embodiment, the present invention relates to pharmaceutical compositions comprising pro-drugs or pharmaceutically acceptable salts of the compounds of the present invention and the use thereof for treating autoimmune diseases or for the prevention of organ transplantation rejection in a subject. In a third embodiment, the present invention relates to processes for the production of novel cyclosporin analogs of the present invention.

US Patent:

58210512, Oct 13, 1998

Filed:

Apr 29, 1997

Appl. No.:

8/840683

Inventors:

Elliot Androphy - Natick MA
Jason J. Chen - Boston MA

Assignee:

New England Medical Center Hospitals - Boston MA

International Classification:

C12Q 170

US Classification:

435 5

Abstract:

An assay for screening test compounds to indentify agents which modulate the binding of an E6-BP polypeptide with a papilloma virus E6 protein. The assay includes combining, as a cell-free system, an E6-binding protein or fragment thereof which binds to the E6 protein, and a test compound, and detecting the formation of a complex which includes the E6 protein and the E6-binding protein. A change in the formation of the complex in the presence of the test compound is indicative of an agent that modulates interaction between an E6 and an E6-binding protein.

US Patent:

6296853, Oct 2, 2001

Filed:

Aug 26, 1999

Appl. No.:

9/384301

Inventors:

Elliot J. Androphy - Natick MA
Jason J. Chen - Boston MA

Assignee:

New England Medical Center Hospitals, Inc. - Boston MA

International Classification:

A61K 3912

US Classification:

4242041

Abstract:

E6-BP polypeptide, nucleic acids encoding E6-BP polypeptides, and uses thereof.

US Patent:

59898046, Nov 23, 1999

Filed:

Nov 14, 1995

Appl. No.:

8/555722

Inventors:

Elliot J. Androphy - Natick MA
Jason J. Chen - Boston MA

Assignee:

New England Medical Center Hospitals, Inc. - Boston MA

International Classification:

C12Q 170
G01N 33574
A61K 3800
C07H 2104

US Classification:

435 5

Abstract:

E6-BP polypeptides, nucleic acids encoding E6-BP polypeptides, and uses thereof.

US Patent:

20190329026, Oct 31, 2019

Filed:

May 10, 2019

Appl. No.:

16/408721

Inventors:

- New York NY, US
Demetrios Papageorgiou - Weston MA, US
Jason Chen - Melrose MA, US

Assignee:

Precision NeuroTechnologies LLC - New York NY

International Classification:

A61N 1/05
A61B 5/00
A61N 1/36
A61B 5/04
A61N 1/372
A61B 5/0478

Abstract:

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

US Patent:

20180117309, May 3, 2018

Filed:

Dec 28, 2017

Appl. No.:

15/856677

Inventors:

- New York NY, US
Demetrios PAPAGEORGIOU - Weston MA, US
Jason CHEN - Melrose MA, US

Assignee:

Precision NeuroTechnologies LLC - New York NY

International Classification:

A61N 1/05
A61B 5/0478
A61N 1/372
A61N 1/36

Abstract:

The present disclosure relates to an array of electrodes on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain.

US Patent:

20180078767, Mar 22, 2018

Filed:

May 3, 2017

Appl. No.:

15/585746

Inventors:

- New York NY, US
Demetrios Papageorgiou - Weston MA, US
Jason Chen - Melrose MA, US

International Classification:

A61N 1/36
A61N 1/05

Abstract:

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

US Patent:

20170061699, Mar 2, 2017

Filed:

Nov 14, 2016

Appl. No.:

15/351430

Inventors:

- Redmond WA, US
Roberto Javier Bojorquez Alfaro - Bothell WA, US
Hae-jin Lee - Seattle WA, US
Jason Chen - Bellevue WA, US
Doyop Kim - Fremont CA, US

International Classification:

G06T 19/00
G06T 7/60

Abstract:

Techniques for generating and superimposing digital signage onto an immersive view. In an exemplary embodiment, certain entities are occluded or otherwise unviewable in an immersive view of an environment. For such entities, digital signage may be generated and superimposed in a suitable area of the immersive view, and further indicating, e.g., directions to such entities from a viewing location, as well as other metadata, such as business name, website, etc. To determine whether a nearby entity is displayed in the immersive view, a planar layout storing geometrical data associated with entities in the vicinity may be loaded and processed.