Jason Wen Chien

US Patent:

20100326218, Dec 30, 2010

Filed:

Sep 26, 2008

Appl. No.:

12/680410

Inventors:

Michael Boeckh - Seattle WA, US
Jason W. Chien - Seattle WA, US
Kieren Marr - Baltimore MD, US
Pierre-Yves Bochud - Pully, CH

International Classification:

G01N 33/00

US Classification:

738658

Abstract:

The present invention provides a method of identifying a subject having a haplotype in a toll-like receptor 4 gene of the subject that is associated with an increased risk of invasive mold infection in a recipient of a transplant from the subject, comprising genotyping the subject for the presence of particular single nucleotide polymorphisms or haplotypes in the toll-like receptor 4 gene of the subject, wherein the detection of said single nucleotide polymorphism(s) and/or haplotype(s) identifies the subject as having a single nucleotide polymorphism and/or haplotype associated with an increased risk of invasive mold infection in a recipient of a transplant from the subject. Also provided herein are methods of identifying an immunocompromised subject as having an increased risk of invasive mold infection and/or increased risk of mortality and/or increased risk of an impaired or altered immune response, by detecting the single nucleotide polymorphisms or haplotypes in the toll-like receptor 4 gene of this invention in the subject.

US Patent:

20120309020, Dec 6, 2012

Filed:

Jun 1, 2012

Appl. No.:

13/487109

Inventors:

Victoria Smith - Burlingame CA, US
Joanne I. Adamkewicz - Belmont CA, US
Susan K. Lyman - South San Francisco CA, US
Jason Chien - Seattle WA, US
Xiaoming Li - Bellevue WA, US
Lixin Shao - Bellevue WA, US
Jeffrey D. Bornstein - Burlingame CA, US

Assignee:

Gilead Biologics, Inc. - Foster City CA

International Classification:

G01N 33/573
G01N 33/574

US Classification:

435 74

Abstract:

The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) polypeptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided.

US Patent:

20090035781, Feb 5, 2009

Filed:

Jul 31, 2008

Appl. No.:

12/183480

Inventors:

Jason W. Chien - Seattle WA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides method of identifying a subject as having an increased risk of developing a Gram negative bacterial infection and/or as having an increased risk of mortality, comprising genotyping the subject for the presence of particular alleles of the lipopolysaccharide binding protein gene, wherein the presence of said allele(s) identifies the subject as having an increased risk of developing a Gram negative bacterial infection and/or of having an increased risk of mortality.

US Patent:

20170327595, Nov 16, 2017

Filed:

Jan 26, 2017

Appl. No.:

15/416940

Inventors:

- Foster City CA, US
Joanne I. Adamkewicz - Belmont CA, US
Victoria Smith - Burlingame CA, US
Susan K. Lyman - South San Francisco CA, US
Jason Chien - Seattle WA, US
Xiaoming Li - Bellevue WA, US
Lixin Shao - Bellevue WA, US

International Classification:

C07K 16/40
G01N 33/573
A61K 39/00

Abstract:

Provided are therapeutic, diagnostic, and prognostic methods for disease, including diseases associated with fibrosis and cancer using agents that bind to, inhibit, and/or detect lysyl oxidase-like 2 (LOXL2), and agents, compositions, kits, assay systems, and devices for use with such methods.

US Patent:

20170269085, Sep 21, 2017

Filed:

Dec 1, 2016

Appl. No.:

15/366986

Inventors:

- Foster City CA, US
Joanne I. Adamkewicz - Belmont CA, US
Susan K. Lyman - South San Francisco CA, US
Jason Chien - Seattle WA, US
Xiaoming Li - Bellevue WA, US
Lixin Shao - Bellevue WA, US
Jeffrey D. Bornstein - Cambridge MA, US

International Classification:

G01N 33/573
C07K 16/40
A61K 39/00

Abstract:

The present disclosure provides an assay to detect and/or quantify circulating lysyl oxidase-like 2 (LOXL2) polypeptides in an individual. The assay is useful in diagnostic and prognostic applications, which are also provided.

US Patent:

20140120102, May 1, 2014

Filed:

Oct 30, 2013

Appl. No.:

14/067740

Inventors:

- Foster City CA, US
Joanne I. ADAMKEWICZ - Belmont CA, US
Victoria SMITH - Burlingame CA, US
Susan K. LYMAN - South San Francisco CA, US
Jason CHIEN - Seattle WA, US
Xiaoming LI - Bellevue WA, US
Lixin SHAO - Bellevue WA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07K 16/40
G01N 33/573

US Classification:

4241391, 435 74, 435 5

Abstract:

Provided are therapeutic, diagnostic, and prognostic methods for disease, including diseases associated with fibrosis and cancer using agents that bind to, inhibit, and/or detect lysyl oxidase-like 2 (LOXL2), and agents, compositions, kits, assay systems, and devices for use with such methods.