Jason Robert Donald

US Patent:

20130344292, Dec 26, 2013

Filed:

Jul 23, 2013

Appl. No.:

13/948364

Inventors:

Greg Clark - Hillsboro OR, US
Todd Hanson - Beaverton OR, US
Scott Edward Fuller - Portland OR, US
Jason Donald - Portland OR, US

Assignee:

FEI Company - Hillsboro OR

International Classification:

H01J 37/30

US Classification:

428157, 4281951, 4251744

Abstract:

A method and system for forming and using a fiducial on a sample to locate an area of interest on the sample, the method comprising forming a fiducial by depositing a block of material on a sample proximal to an area of interest on the sample, the block of material extending from the surface of the sample to a detectable extent above the surface of the sample; and milling, using a charged particle beam, a predetermined pattern into at least two exposed faces of the block of material; subsequent to forming the fiducial, detecting the location of the area of interest by detecting the location of the fiducial; and subsequent to detecting the location of the area of interest, imaging or milling the area of interest with a charged particle beam.

US Patent:

8502172, Aug 6, 2013

Filed:

Jun 26, 2012

Appl. No.:

13/533870

Inventors:

Cliff Bugge - Portland OR, US
Greg Clark - Hillsboro OR, US
Todd Hanson - Beaverton OR, US
Scott Edward Fuller - Portland OR, US
Jason Donald - Portland OR, US

Assignee:

FEI Company - Hillsboro OR

International Classification:

H01J 37/30

US Classification:

2504921, 2504922

Abstract:

A method and system for forming and using a fiducial on a sample to locate an area of interest on the sample, the method comprising forming a fiducial by depositing a block of material on a sample proximal to an area of interest on the sample, the block of material extending from the surface of the sample to a detectable extent above the surface of the sample; and milling, using a charged particle beam, a predetermined pattern into at least two exposed faces of the block of material; subsequent to forming the fiducial, detecting the location of the area of interest by detecting the location of the fiducial; and subsequent to detecting the location of the area of interest, imaging or milling the area of interest with a charged particle beam.

US Patent:

20220364127, Nov 17, 2022

Filed:

Apr 26, 2022

Appl. No.:

17/729056

Inventors:

- CAMBRIDGE MA, US
Souvik GHOSH - Walnut Creek CA, US
Christopher PIRIE - Seattle WA, US
Jason DONALD - Lexington MA, US
Aaron LOVE - Boston MA, US
Hong NAN - Daly City CA, US
Hsien-Chung TSENG - Cambridge MA, US
Christine Nicole S. SANTOS - Newton MA, US
Ryan PHILIPPE - Somerville MA, US

International Classification:

C12P 5/00
C12N 9/02
C12N 9/04
C12N 9/10

Abstract:

In various aspects and embodiments, the invention relates to bacterial strains and methods for making terpene and terpenoid products. The invention provides bacterial strains with improved carbon flux through the MEP pathway, to thereby increase terpene and/or terpenoid product yield by fermentation with carbon sources such as glucose.

US Patent:

20220251607, Aug 11, 2022

Filed:

Apr 26, 2022

Appl. No.:

17/729096

Inventors:

- Cambridge MA, US
Ryan LIM - Cambridge MA, US
Jason DONALD - Lexington MA, US
Hsien-Chung TSENG - Cambridge WA, US
Christine Nicole S. SANTOS - Newton MA, US
Ryan PHILIPPE - Somerville MA, US

International Classification:

C12P 5/00
C12N 9/02
C12N 15/52
C12P 7/04

Abstract:

The invention relates to methods and bacterial strains for making terpene and terpenoid products, the bacterial strains having improved carbon pull through the MEP pathway and to a downstream recombinant synthesis pathway.

US Patent:

20230042171, Feb 9, 2023

Filed:

Dec 16, 2020

Appl. No.:

17/785488

Inventors:

- Cambridge MA, US
Ryan N. PHILIPPE - Orleans, CA
Ajikumar Parayil KUMARAN - Cambridge MA, US
Christine Nicole S. SANTOS - Cambridge MA, US
Jason Eric DONALD - Cambridge MA, US
Christopher FREI - Cambridge MA, US
Aaron LOVE - Cambridge MA, US
Kaitlin CHAMBERS - Cambridge MA, US
Joyce SAMSON - Cambridge MA, US
Christopher TOOMEY - Cambridge MA, US

International Classification:

C12P 17/02
C12N 9/02
C12N 9/14
C12P 19/18
C12P 19/56
C12P 5/00

Abstract:

The present invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog.V), Mogroside VI (Mog.VI), Iso-Mogroside V (Isomog.V), siamenoside, and glycosylation products that are minor products in . The invention provides engineered enzymes and engineered host cells for producing mogrol glycosylation products, such as Mog.V, Mog.VI, and Isomog.V, at high purity and/or yield. The present technology further provides methods of making products containing mogrol glycosides, such as Mog.V, Mog.VI, and Isomog.V, including food products, beverages, oral care products, sweeteners, and flavoring products.

US Patent:

20210254107, Aug 19, 2021

Filed:

Sep 6, 2019

Appl. No.:

17/273567

Inventors:

- Cambridge MA, US
AJIKUMAR PARAYIL KUMARAN - Cambridge MA, US
CHRISTINE NICOLE S. SANTOS - Cambridge MA, US
JASON DONALD - Cambridge MA, US
STEPHEN SARRIA - Cambridge MA, US

International Classification:

C12P 7/26
C12N 15/52
C12N 9/04
C12N 9/02
C12N 9/10
C12N 9/88

Abstract:

The present disclosure provides methods and compositions for producing rotundone. In various aspects, the present disclosure provides enzymes, polynucleotides encoding said enzymes, and recombinant microbial host cells (or microbial host strains) for the production of rotundone. In some embodiments, the present disclosure provides microbial host cells for producing rotundone at high purity and/or yield, from either enzymatic transformation of α-guaiene, or from sugar or other carbon source. The present disclosure further provides methods of making products containing rotundone, including flavor or fragrance products, among others.

US Patent:

20210207078, Jul 8, 2021

Filed:

Jan 19, 2021

Appl. No.:

17/151871

Inventors:

- Cambridge MA, US
Adel GHADERI - Cambridge MA, US
Jason Eric DONALD - Cambridge MA, US
Christine Nicole S. SANTOS - Cambridge MA, US
Ajikumar Parayil KUMARAN - Cambridge MA, US

International Classification:

C12N 1/20
C12N 1/16
C12N 1/26
C12P 5/00

Abstract:

Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a bioreactor medium, the medium comprising an aqueous phase and an extraction phase. The composition of the extraction phase, and the relevant amount with respect to the aqueous phase, enhances production of the secondary metabolite from microbial cells and/or enhances extracellular transfer of the metabolite.

US Patent:

20210022373, Jan 28, 2021

Filed:

Apr 29, 2020

Appl. No.:

16/862214

Inventors:

- Cambridge MA, US
Ajikumar Parayil KUMARAN - Cambridge MA, US
Jason DONALD - Cambridge MA, US
Krishna PATEL - Cambridge MA, US
Swati GUPTA - Cambridge MA, US
Ryan LIM - Cambridge MA, US
Liwei LI - Cambridge MA, US

International Classification:

A23L 2/60
A23L 27/30
C12P 19/56
C12N 9/10
C12N 9/02

Abstract:

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.