Jason Ramos Fernandez

US Patent:

20100137213, Jun 3, 2010

Filed:

Oct 29, 2009

Appl. No.:

12/608553

Inventors:

Jason E. Fernandez - Brookline MA, US
Daniel A. Dixon - Arlington MA, US
Andrea Paulson - Somerville MA, US

Assignee:

WYETH - Madison NJ

International Classification:

A61K 38/16
C12P 21/06
G01N 11/00
G06Q 90/00

US Classification:

514 12, 435 691, 73 5301, 705500

Abstract:

The invention relates to formulations of single domain antigen binding molecules, e.g., nanobody molecules, in particular formulations of TNF-binding nanobody molecules. The single domain antigen binding molecules can include one or more single binding domains that interact with, e.g., bind to, one or more target proteins. The formulations are useful, e.g., as pharmaceutical formulations. Method of preparing, and using the formulations described herein, to treat, e.g., TNF-associated disorders, are also disclosed.