Jason B Garrison

US Patent:

20090170865, Jul 2, 2009

Filed:

Nov 25, 2008

Appl. No.:

12/323073

Inventors:

Natasha Kyprianou - Lexington KY, US
Jason B. Garrison - San Diego CA, US
Ching-Shih Chen - Columbus OH, US

Assignee:

University of Kentucky Research Foundation - Lexington KY

International Classification:

A61K 31/517
C12N 5/06

US Classification:

51425217, 435375

Abstract:

Provided is a method of inhibiting the growth of prostate cancer cells comprising administering an effective amount of DZ-50 (2-[4-biphenyl-4-sulfonyl)-piperazin-1-yl]-6,7-diisopropoxyquinazolin-4-yl-amine) to a patient in need thereof. In another aspect, a method is provided for inhibiting the initiation of prostate cancer comprising administering an effective amount of DZ-50 to a patient in need thereof. In yet another aspect, a method is provided for inhibiting the formation of a prostate tumor-derived metastatic lesion comprising administering an effective amount of DZ-50 to a patient in need thereof. In any of the aforementioned methods, a quinazoline-based drug which induces apoptosis of a prostate cancer cell may be coadministered with DZ-50. Also provided is a composition comprising DZ-50, a quinazoline-based drug which induces apoptosis of a prostate cancer cell, and a pharmaceutically acceptable carrier.

US Patent:

8377948, Feb 19, 2013

Filed:

Jun 17, 2005

Appl. No.:

11/570966

Inventors:

Ching-Shih Chen - Arlington OH, US
Jason B. Garrison - Alexandria VA, US
Natasha Kyprianou - Lexington KY, US

Assignee:

The Ohio State University Research Foundation - Columbus OH

International Classification:

A01N 43/54
A61K 31/517
C07D 239/72

US Classification:

5142661, 544283

Abstract:

Antitumor compounds based on the α1-adrenoceptor antagonist, doxazosin, as well as compositions and methods of use. The disclosed compounds induce apoptosis in cancer cells.