Jason P Gorman

US Patent:

20200286706, Sep 10, 2020

Filed:

Mar 5, 2020

Appl. No.:

16/809736

Inventors:

- College Park MD, US
- Gaithersburg MD, US
June LAU - Rockville MD, US
Jason J. GORMAN - Silver Spring MD, US

International Classification:

H01J 37/20

Abstract:

A sample carrier for in situ transmission electron microscopy (TEM) has a dielectric substrate with a conductive layer that forms a coplanar waveguide. The coplanar waveguide has a first and second leads formed by the conductive layer. The first lead is between an adjacent pair of second leads and is spaced from the second leads by a respective gap. The coplanar waveguide is configured to transmit an electrical signal to a specimen held by the sample carrier, in particular, an electrical signal having a frequency in the radio-frequency (RF) regime (3 kHz-300 GHz), for example, up to 100 GHz. The sample carrier may be mounted to a TEM sample holder, which supports the sample carrier within a vacuum chamber of the microscope and provides electrical connection between the leads of the sample carrier and an RF source external to the vacuum chamber.

US Patent:

20190389915, Dec 26, 2019

Filed:

Aug 30, 2019

Appl. No.:

16/557894

Inventors:

- Bethesda MD, US
Marie Pancera - Seattle WA, US
Tongqing Zhou - Boyds MD, US
Ivelin Georgiev - Nashville TN, US
Michael Gordon Joyce - Washington DC, US
Priyamvada Acharya - Fort Lee NJ, US
Jason Gorman - Washington DC, US
Yongping Yang - Potomac MD, US
Guillaume Stewart-Jones - Bethesda MD, US
Rita Chen - Bethesda MD, US
John Mascola - Rockville MD, US
Baoshan Zhang - Bethesda MD, US
Cheng Cheng - Bethesda MD, US
Mallika Sastry - Rockville MD, US

Assignee:

The U.S.A., as represented by the Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

C07K 14/435
A61K 39/21
C07K 16/10
G01N 33/569
A61K 39/12
C07K 14/005

Abstract:

HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

US Patent:

20180319846, Nov 8, 2018

Filed:

Jul 2, 2018

Appl. No.:

16/025858

Inventors:

- Bethesda MD, US
Barney S. Graham - Rockville MD, US
Jason S. McLellan - Austin TX, US
Jeffrey Boyington - Clarksburg MD, US
Lei Chen - Rockville MD, US
Man Chen - Bethesda MD, US
Ivelin Stefanov Georgiev - Nashville TN, US
Jason Gorman - Washington DC, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Gilad Ofek - Gaithersburg MD, US
Marie Pancera - Seattle WA, US
Mallika Sastry - Rockville MD, US
Cinque Soto - Rockville MD, US
Sanjay Srivatsan - Lilburn GA, US
Guillaume Stewart-Jones - Bethesda MD, US
Yongping Yang - Potomac MD, US
Baoshan Zhang - Bethesda MD, US
Tongqing Zhou - Boyds MD, US

Assignee:

The United States of America,as represented by the Secretary,Department of Helath and Human Services - Bethesda MD

International Classification:

C07K 14/005
A61K 39/155
C12N 7/00
A61K 39/12
G01N 33/564
A61K 39/00

Abstract:

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

US Patent:

20170233441, Aug 17, 2017

Filed:

Sep 4, 2015

Appl. No.:

15/508885

Inventors:

- Bethesda MD, US
Marie Pancera - Seattle WA, US
Tongqing Zhou - Boyds MD, US
Ivelin Georgiev - Nashville TN, US
Michael Gordon Joyce - Bethesda MD, US
Priyamvada Acharya - Fort Lee NJ, US
Jason Gorman - Washington DC, US
Yongping Yang - Potomac MD, US
Aliaksandr Druz - Germantown MD, US
Guillaume Stewart-Jones - Bethesda MD, US
Rita Chen - Bethesda MD, US
Ulrich Baxa - Frederick MD, US
John Mascola - Rockville MD, US
Rebecca Lynch - Washington DC, US
Baoshan Zhang - Bethesda MD, US
Cheng Cheng - Rockville MD, US

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD

International Classification:

C07K 14/435
A61K 39/21
G01N 33/569
C07K 16/10

Abstract:

HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

US Patent:

20160046675, Feb 18, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/776651

Inventors:

- Bethesda MD, US
Barney S. Graham - Rockville MD, US
Jason S. McLellan - Norwich VT, US
Jeffrey Boyington - Clarksburg MD, US
Lei Chen - Rockville MD, US
Man Chen - Bethesda MD, US
Ivelin Stefanov Georgiev - Gaithersburg MD, US
Jason Gorman - Washington DC, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Gilad Ofek - Gaithersburg MD, US
Marie Pancera - McLean VA, US
Mallika Sastry - Rockville MD, US
Cinque Soto - Rockville MD, US
Sanjay Srivatsan - Lilburn GA, US
Guillaume Stewart-Jones - Bethesda MD, US
Yongping Yang - Potomac MD, US
Baoshan Zhang - Bethesda MD, US
Tongqing Zhou - Boyds MD, US

Assignee:

The USA, as represented by the Secretary, Departm- ent of Health and Human Service - Bethesda MD

International Classification:

C07K 14/005
A61K 39/155
G01N 33/564
C12N 7/00

Abstract:

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

US Patent:

20140348865, Nov 27, 2014

Filed:

Sep 7, 2012

Appl. No.:

14/344589

Inventors:

- Bethesda MD, US
- Baltimore MD, US
- Seattle WA, US
Jason Gorman - Washington DC, US
Mallika Sastry - Rockville MD, US
Kaifan Dai - La Jolla CA, US
Tongqing Zhou - Boyds MD, US
John Mascola - Rockville MD, US
Gary Nabel - Cambridge MA, US
Masaru Kanekiyo - Chevy Chase MD, US
Yongping Yang - Potomac MD, US
Jiang Zhu - Ashburn VA, US
Lai-Xi Wang - Ellicott City MD, US
William Schief - Encinitas CA, US
Chris Carrico - San Francisco CA, US
Mohammed Amin - Baltimore MD, US

International Classification:

C07K 14/005
C12N 7/00

US Classification:

4241881, 530405, 536 2372, 4353201

Abstract:

Disclosed are HIV immunogens. Also disclosed are nucleic acids encoding these immunogens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.