Jason P Holder

US Patent:

20120171735, Jul 5, 2012

Filed:

Jun 15, 2010

Appl. No.:

13/378479

Inventors:

Anthony John Sinskey - Boston MA, US
Daniel MacEachran - Cambridge MA, US
Kazuhiko Kurosawa - Somerville MA, US
Paolo Boccazzi - Cambridge MA, US
Jason W. Holder - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12P 7/64
C12N 9/02
C07K 14/195
C12N 1/21

US Classification:

435134, 4352523, 435189, 530350

Abstract:

The invention relates to production of triacylglycerols in cells.

US Patent:

20190330599, Oct 31, 2019

Filed:

Jul 12, 2019

Appl. No.:

16/510643

Inventors:

- Cambridge MA, US
Jason Holder - Swampscott MA, US

International Classification:

C12N 7/00
C12N 15/70
C12Q 1/70
C12Q 1/18

Abstract:

The present disclosure provides compositions including recombinant K1E bacteriophages, methods for making the same, and uses thereof. The recombinant K1E bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.

US Patent:

20190309265, Oct 10, 2019

Filed:

Jun 20, 2019

Appl. No.:

16/447209

Inventors:

- Cambridge MA, US
Georgiana Kourepenos - Acton MA, US
Parker Dow - Boston MA, US
Jason Holder - Swampscott MA, US

International Classification:

C12N 7/00
C12Q 1/04
C12Q 1/02
C12N 15/74

Abstract:

The present disclosure provides compositions including recombinant B 11 bacteriophages, methods for making the same, and uses thereof. The recombinant B 11 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.

US Patent:

20190078133, Mar 14, 2019

Filed:

Sep 6, 2018

Appl. No.:

16/123875

Inventors:

- Cambridge MA, US
Quin Christensen - Cambridge MA, US
Kenneth T. Kotz - Cambridge MA, US
Jason Holder - Swampscott MA, US

International Classification:

C12Q 1/10
C12Q 1/18
C12N 7/00

Abstract:

The present disclosure provides compositions and methods for identifying bacteria and profiling their antibiotic susceptibility. In particular, the methods and compositions of the present technology permit the detection of low concentrations of bacterial cells (e.g.,

US Patent:

20190048325, Feb 14, 2019

Filed:

Aug 7, 2018

Appl. No.:

16/057416

Inventors:

- Cambridge MA, US
Miles T. Rogers - Boston MA, US
Connor McBrine - Somerville MA, US
Jason W. Holder - Swampscott MA, US

International Classification:

C12N 7/02
C12N 15/63

Abstract:

The present disclosure provides methods of generating recombinant bacteriophage genomes via semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.

US Patent:

20180346905, Dec 6, 2018

Filed:

May 31, 2018

Appl. No.:

15/994002

Inventors:

- Cambridge MA, US
Jason Holder - Swampscott MA, US

International Classification:

C12N 15/10
C12N 9/22
C12N 15/113

Abstract:

The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.

US Patent:

20180265833, Sep 20, 2018

Filed:

Sep 2, 2016

Appl. No.:

15/756784

Inventors:

John COPPETA - Windham NH, US
John FUMO - Kailua Kona HI, US
Jason W. HOLDER - Swampscott MA, US
- Cambridge MA, US

International Classification:

C12M 1/34
C12M 1/02

Abstract:

According to various aspects and embodiments, an integrated sensor system is provided. In one example, such an integrated sensor system includes at least one unit cell, an analysis device, and a controller. The at least one unit cell may include an activation chamber containing an activation fluid, a biological chamber containing a biological component, a first membrane disposed in between the activation chamber and the biological chamber, an assay chamber configured to receive a sample, and a second membrane disposed in between the assay chamber and the biological chamber.

US Patent:

20180223262, Aug 9, 2018

Filed:

Feb 9, 2018

Appl. No.:

15/893094

Inventors:

- Cambridge MA, US
Jason Holder - Swampscott MA, US

International Classification:

C12N 7/00
C12Q 1/70
C07K 14/005

Abstract:

The present disclosure provides compositions including recombinant K1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant K1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.