Jason O Houtchens

US Patent:

7977315, Jul 12, 2011

Filed:

Nov 16, 2007

Appl. No.:

11/941914

Inventors:

Seth D. Rose - Tempe AZ, US
Karl J. Okolotowicz - Goleta CA, US
Rosemarie F. Hartman - Tempe AZ, US
Jason Houtchens - Tempe AZ, US

Assignee:

Arizona Biomedical Research Commission - Pheonix AZ

International Classification:

A61P 35/00
A61K 38/04
A61K 38/05

US Classification:

514 193, 514 219, 514 2191

Abstract:

Conjugated nitro alkene compounds hamper or prevent proliferation of cancer cells in cell culture and in cancer patients, which can result in a decrease in tumor size and/or disappearance of the cancer. The compounds may act by interference with cancer cell biochemistry, in which isoprenoid groups such as farnesyl and geranylgeranyl become bonded to various oncogenic proteins such as Ras, RhoA, RhoB, or some other growth-related cellular protein(s).

US Patent:

20050026812, Feb 3, 2005

Filed:

Jul 29, 2004

Appl. No.:

10/901082

Inventors:

Seth Rose - Tempe AZ, US
Karl Okolotowicz - Goleta CA, US
Rosemarie Hartman - Tempe AZ, US
Jason Houtchens - Tempe AZ, US

Assignee:

Arizona Disease Control Research Commission - Phoenix AZ

International Classification:

A61K038/00
A61K031/66
C07K014/00
A61K031/04
A61K031/075

US Classification:

514002000, 514712000, 514740000, 514716000, 568044000, 568583000, 568924000, 514357000, 514408000, 514561000, 530300000, 546329000, 548567000

Abstract:

Conjugated nitro alkene compounds hamper or prevent proliferation of cancer cells in cell culture and in cancer patients, which can result in a decrease in tumor size and/or disappearance of the cancer. The compounds may act by interference with cancer cell biochemistry, in which isoprenoid groups such as farnesyl and geranylgeranyl become bonded to various oncogenic proteins such as Ras, RhoA, RhoB, or some other growth-related cellular protein(s).