Jason S Katz

US Patent:

7550478, Jun 23, 2009

Filed:

Jun 22, 2006

Appl. No.:

11/473273

Inventors:

Christopher J. Dinsmore - Newton MA, US
Ana Esther Gabarda Ortega - Madrid, ES
David J. Guerin - Natick MA, US
James P. Jewell - Sandwich MA, US
Jason D. Katz - Newton Highlands MA, US
Jongwon Lim - Lexington MA, US
Michelle R. Machacek - Boston MA, US
Ryan D. Otte - Newton Centre MA, US
Jonathan R. Young - Southborough MA, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A01N 43/42
A61K 31/44
C07D 221/00

US Classification:

514290, 546 93

Abstract:

The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

US Patent:

8455477, Jun 4, 2013

Filed:

Jul 27, 2009

Appl. No.:

13/057325

Inventors:

Jason Katz - Newton Highlands MA, US
James Jewell - Somerville MA, US
Joon Jung - Newton MA, US
Solomon Kattar - Arlington MA, US
Yongquan Hou - Cambridge MA, US
Rachel MacCoss - Brookline MA, US
Satoru Ito - Tsukuba, JP

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
MSD K.K. - Tokyo

International Classification:

A61K 31/437
A61K 31/438
A61K 31/4439
A61K 31/444
A61K 31/5377
A61K 31/397
A61K 31/505
A61K 31/495
A61K 31/496
A61K 31/50
C07F 7/02
C07D 487/02
C07D 413/14
C07D 401/02
C07D 401/14
C07D 221/20

US Classification:

51421018, 5142332, 5142355, 51425201, 51425213, 51425505, 514256, 514278, 514300, 544124, 544127, 544238, 544333, 544360, 544362, 544405, 546 14, 546 15, 546 16, 546121

Abstract:

The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.

US Patent:

8518911, Aug 27, 2013

Filed:

Jul 27, 2009

Appl. No.:

13/057510

Inventors:

Jason D. Katz - Newton Highlands MA, US
Sandra L. Knowles - Cambridge MA, US
James P. Jewell - Sandwich MA, US
David L. Sloman - Boston MA, US
Matthew G. Stanton - Marlton NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/675
A61K 31/437
A61K 31/496
A61K 31/397

US Classification:

514 80, 514300, 5142332, 51425304, 514278, 514221, 546121, 546 18, 546 21, 544362, 544127, 540569

Abstract:

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

US Patent:

8639838, Jan 28, 2014

Filed:

May 31, 2013

Appl. No.:

13/906645

Inventors:

Tim Von Kaenel - Coto de Casa CA, US
Jeffrey Wang - Horsham PA, US
Jeffrey Odell - Newport Beach CA, US
David Starr - New York NY, US
Jason Katz - New York NY, US

Assignee:

SimpleAir, Inc. - Plano TX

International Classification:

G06F 15/16
G08B 5/22

US Classification:

709236, 340 729

Abstract:

A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

US Patent:

20130040933, Feb 14, 2013

Filed:

Apr 21, 2011

Appl. No.:

13/643323

Inventors:

Brandon Cash - Framingham MA, US
Christian Fischer - Natick MA, US
Yudith Garcia - Brookline MA, US
Joon Jung - Newton MA, US
Jason Katz - Newton Highlands MA, US
June Kim - West Chester PA, US
Alexey Rivkin - Emeryville CA, US
Adam Schell - Decatur GA, US
Tony Siu - Brookline MA, US
David Witter - Norfolk MA, US
Hua Zhou - Acton MA, US

International Classification:

A61K 31/497
C07D 519/00
A61K 31/5377
A61K 31/541
A61K 31/4985
A61P 35/00
A61P 11/06
A61P 37/00
A61P 1/04
A61P 25/00
A61P 3/10
C07D 471/04
A61P 19/02

US Classification:

51421018, 544405, 544357, 544120, 544 582, 544350, 544295, 51425505, 51425211, 5142345, 540524, 51421208, 5142282, 514249

Abstract:

The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof. Compounds of formula I are inhibitors of Janus kinases and as such are useful for the treatment of various diseases and conditions mediated by said enzymes, such as rheumatoid arthritis, asthma, COPD, ALS, and the like.

US Patent:

20130282872, Oct 24, 2013

Filed:

May 30, 2013

Appl. No.:

13/905393

Inventors:

Tim Von Kaenel - Coto de Casa CA, US
Jeffrey Wang - Horsham PA, US
Jeffrey Odell - Newport Beach CA, US
David Starr - New York NY, US
Jason Katz - New York NY, US

International Classification:

H04L 29/08

US Classification:

709219

Abstract:

A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

US Patent:

20220387397, Dec 8, 2022

Filed:

Oct 23, 2019

Appl. No.:

17/287837

Inventors:

- Basel, CH
Shankar VENKATRAMAN - Lansdale PA, US
Shomir GHOSH - Brookline MA, US
Jason KATZ - Newton MA, US
Hans Martin SEIDEL - Concord MA, US

International Classification:

A61K 31/426
A61P 29/00
A61P 1/00
A61K 45/06
A61K 39/395
A61K 31/341
C07D 307/64
C07D 277/36
C07C 311/51
A61K 31/18

Abstract:

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

US Patent:

20220339169, Oct 27, 2022

Filed:

Jul 2, 2019

Appl. No.:

17/252630

Inventors:

- Basel, CH
Shomir GHOSH - Brookline MA, US
Gary GLICK - Ann Arbor MI, US
Jason KATZ - Newton MA, US
William R. ROUSH - Boston MA, US
Hans Martin SEIDEL - Concord MA, US
Shankar VENKATRAMAN - Lansdale PA, US
David Guenther WINKLER - Arlington MA, US

International Classification:

A61K 31/64
C07K 16/24
A61K 45/06
C12Q 1/6827
C12N 15/113

Abstract:

Provided herein are methods of treating a subject that include administering a therapeutically effective amount of an NLPR3 antagonist or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having a cell that has an elevated level of NLRP3 inflammasome activity and/or expression as compared to a reference level. Provided herein are methods of treating a subject, methods of selecting a treatment for a subject, methods of selecting a subject for treatment, and methods of selecting a subject for participation in a clinical study that include the administration of a therapeutically effective amount of an NLRP3 antagonist. Also provided are methods of treating a subject having resistance to an anti-TNFα agent and methods of determining the efficacy of treatment with an anti-TNFα agent. Also provided are methods of treating a subject with a combination of an NLRP3 antagonist and an anti-TNFα agent.