Jason A Long

US Patent:

20160024159, Jan 28, 2016

Filed:

Mar 12, 2014

Appl. No.:

14/773756

Inventors:

- Thousand Oaks CA, US
Jerry Ryan HOLDER - Simi Valley CA, US
Malgorzata WANSKA - Oak Park CA, US
Christopher M. TEGLEY - Thousand Oaks CA, US
James R. FALSEY - Moorpark CA, US
Elizabeth M. DOHERTY - Thousand Oaks CA, US
Leslie P. MIRANDA - Thousand Oaks CA, US
Kaustav BISWAS - Agoura Hills CA, US
Bin WU - Thousand Oaks CA, US
Kelvin SHAM - Thousand Oaks CA, US
Jason C. LONG - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07K 14/435
A61K 38/17
A61K 47/48

Abstract:

Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted Na1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of Na1.7. Other embodiments are conjugated embodiments of the inventive composition of matter and pharmaceutical compositions containing the inventive composition of matter. Isolated nucleic acids encoding some embodiments of inventive polypeptides and expression vectors, and recombinant host cells containing them are disclosed. A method of treating or preventing pain is also disclosed.