Jason K Meier

US Patent:

20090074884, Mar 19, 2009

Filed:

Jun 18, 2008

Appl. No.:

12/141751

Inventors:

Jason Chesney - Louisville KY, US
John O. Trent - Louisville KY, US
Sucheta Telang - Louisville KY, US
Brian Clem - Louisville KY, US
Jason Meier - Louisville KY, US

International Classification:

A61K 33/24
C12N 9/99
C12N 5/08
A61K 31/444
A61P 35/00
C12Q 1/42
A61K 31/4709
A61K 31/44

US Classification:

424649, 435184, 435375, 435377, 514332, 514355, 514314, 435 21

Abstract:

A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.

US Patent:

20110009412, Jan 13, 2011

Filed:

May 24, 2007

Appl. No.:

12/301783

Inventors:

Robert A. Mitchell - Louisville KY, US
John O. Trent - Louisville KY, US
Jason B. Meier - Louisville KY, US

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

International Classification:

A61K 31/53
C12N 5/09
C07H 21/00
C07H 21/02
A61K 31/505
A61P 35/00

US Classification:

514243, 435375, 536 245, 514269

Abstract:

Methods of inhibiting one or more biological activities of Macrophage migration inhibitory factor (MIF) polypeptides are provided using an MIF inhibitory compound. The methods include therapeutic methods for treating cancers and inflammatory diseases.

US Patent:

20130059852, Mar 7, 2013

Filed:

Apr 8, 2011

Appl. No.:

13/639864

Inventors:

John O. Trent - Louisville KY, US
Jason B. Meier - Louisville KY, US
Kelby B. Napier - St. Louis MO, US

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY

International Classification:

A61K 31/4184
A61K 31/36
C07D 403/06
A61K 31/41
C07D 249/12
A61K 31/4196
C07D 241/04
A61K 31/495
C07D 401/06
A61K 31/454
C07C 211/25
A61K 31/132
C07D 235/14
C07D 401/12
A61K 31/473
C07D 403/12
A61K 31/4025
C07D 215/54
A61K 31/47
C07D 471/10
A61K 31/499
C07D 471/04
A61K 31/437
C07D 209/86
A61K 31/403
C07D 235/30
C07D 319/20
A61K 31/4545
C07D 413/12
A61K 31/5377
C07D 217/24
A61K 31/472
A61K 31/498
C07D 209/40
A61K 31/404
A61P 35/00
A61P 9/00
A61P 35/04
A61P 31/18
A61P 31/22
A61P 3/10
A61P 13/12
A61P 35/02
C12N 5/071
C12N 5/10
C07D 317/58

US Classification:

5142368, 549443, 514464, 548252, 514381, 5482644, 514384, 544395, 51425503, 546199, 514322, 564512, 514659, 5483097, 514394, 546101, 514290, 5483054, 548520, 514422, 546159, 514313, 544231, 514249, 546 86, 514292, 548444, 514411, 5483074, 514388, 549366, 514452, 546194, 514318, 544137, 546142, 514309, 544356, 548483, 514418, 435375, 435366, 435358, 435354, 435363

Abstract:

Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).