Jason T O'Neill

US Patent:

20230079602, Mar 16, 2023

Filed:

Sep 15, 2022

Appl. No.:

17/945299

Inventors:

- Lexington MA, US
Jennifer LACHEY - Lincoln MA, US
Claire TSENG - Newton MA, US
Jason O'NEILL - Lake Forest Park WA, US
Henning THØGERSEN - Farum, DK
Elissa FURUTANI - Belmont MA, US

International Classification:

C07K 14/71
A61P 21/00
A61P 19/08
A61P 7/06
A61P 11/00
A61P 3/04
A61P 7/04
A61P 7/00

Abstract:

The invention features polypeptides that include an extracellular ActRII chimera. In some embodiments, a polypeptide of the invention includes an extracellular ActRII chimera fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving weakness and atrophy of muscles, bone damage, low red blood cell levels (e.g., anemia or blood loss), low platelet levels (e.g., thrombocytopenia), low neutrophil levels (e.g., neutropenia), fibrosis, metabolic disorders, and/or pulmonary hypertension.

US Patent:

20190008974, Jan 10, 2019

Filed:

Dec 11, 2015

Appl. No.:

14/967167

Inventors:

- Thousand Oaks CA, US
Michelle BLAKE - Arlington MA, US
Jason Charles O'NEILL - Brier WA, US
Gunasekaran KANNAN - Newbury Park CA, US
Jiangchun XU - San Diego CA, US
Mark Edward TOMETSKO - Seattle WA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 47/48
C07K 16/28
A61K 31/395
A61K 39/395
A61K 45/06

Abstract:

The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.

US Patent:

20150344583, Dec 3, 2015

Filed:

Dec 5, 2013

Appl. No.:

14/649469

Inventors:

- Thousand Oaks CA, US
Michelle BLAKE - Arlington MA, US
Jason Charles O'NEILL - Brier WA, US
Gunasekaran KANNAN - Newbury Park CA, US
Jiangchun XU - San Diego CA, US
Mark Edward TOMETSKO - Seattle WA, US
Zhulun WANG - Palo Alto CA, US
Athena SUDOM - San Mateo CA, US

International Classification:

C07K 16/28
A61K 45/06
A61N 5/10
A61K 47/48

Abstract:

The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates and uses thereof.

US Patent:

20140161828, Jun 12, 2014

Filed:

Dec 5, 2013

Appl. No.:

14/098275

Inventors:

- Thousand Oaks CA, US
Michelle BLAKE - Arlington MA, US
Jason Charles O'NEILL - Brier WA, US
Gunasekaran KANNAN - Newbury Park CA, US
Jiangchun XU - San Diego CA, US
Mark Edward TOMETSKO - Seattle WA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 47/48
A61K 31/537
A61K 45/06
C07K 16/18

US Classification:

4241811, 435 696, 435331, 435243, 4353201, 5303873, 5303879, 5303881, 53038815, 5303919, 536 2353

Abstract:

The present invention relates to BCMA (B-Cell Maturation Antigen) antigen binding proteins, such as antibodies, polynucleotide sequences encoding said antigen binding proteins, and compositions and methods for diagnosing and treating diseases. The present invention also relates to BCMA antibody drug conjugates.