Jason Daniel O'Neill

US Patent:

20190085054, Mar 21, 2019

Filed:

Dec 4, 2018

Appl. No.:

16/209239

Inventors:

- Thousand Oaks CA, US
Jason Charles O'Neill - Brier WA, US
Randal R. Ketchem - Snohomish WA, US
Randy Ira Hecht - Raleigh NC, US
Edward J. Belouski - Thousand Oaks CA, US
Mark Leo Michaels - Encino CA, US

International Classification:

C07K 14/81
C12N 9/64
A61K 38/00

Abstract:

There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.

US Patent:

20170022285, Jan 26, 2017

Filed:

Oct 10, 2016

Appl. No.:

15/289797

Inventors:

- THOUSAND OAKS CA, US
Jason C. O'NEILL - BRIER WA, US
Ian FOLTZ - BURNABY, CA
Randall R. KETCHEM - SNOHOMISH WA, US
Julia C. PIASECKI - SEATTLE WA, US

Assignee:

AMGEN INC. - THOUSAND OAKS CA

International Classification:

C07K 16/28

Abstract:

Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a variety of immunotherapy treatments, including treatment of various cancers and infections.

US Patent:

20160031969, Feb 4, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/775482

Inventors:

- Thousand Oaks CA, US
Jason Charles O'Neill - Brier WA, US
Randal R. Ketchem - Snohomish WA, US
Randy Ira Hecht - Raleigh NC, US
Edward J. Belouski - Thousand Oaks CA, US
Mark Leo Michaels - Encino CA, US

Assignee:

AMGEN INC. - Thousands Oaks CA

International Classification:

C07K 14/81

Abstract:

There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.

US Patent:

20150064204, Mar 5, 2015

Filed:

Aug 28, 2014

Appl. No.:

14/472116

Inventors:

- THOUSAND OAKS CA, US
Jason C. O'NEILL - Brier WA, US
Ian FOLTZ - BURNABY, CA
Randal R. KETCHEM - SNOHOMISH WA, US
Julia C. PIASECKI - SEATTLE WA, US

International Classification:

C07K 16/28
A61K 45/06
A61K 39/395

US Classification:

4241741, 5303897, 53038822, 5303873, 536 2353

Abstract:

Antigen binding proteins that activate GITR are provided. Nucleic acids encoding the antigen binding proteins and vectors and cells containing such nucleic acids are also provided. The antigen binding proteins have value in therapeutic methods in which it is useful to to stimulate GITR signaling, thereby inducing or enhancing an immune response in a subject. Accordingly, the antigen binding proteins have utility in a varienty of immunotherapy treatments, including treatment of various cancers and infections.

US Patent:

20140274874, Sep 18, 2014

Filed:

Mar 12, 2014

Appl. No.:

14/207178

Inventors:

- Thousand Oaks CA, US
Jason Charles O'NEILL - Brier WA, US
Jeonghoon SUN - San Diego CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07K 14/47

US Classification:

514 16, 530350, 536 235, 4353201, 43525233, 435 691, 514 212, 4352542, 43525411, 435419, 435414, 435411, 435325, 435366, 435363, 435352, 435353, 435354, 435348, 435365, 435358, 435367, 435369, 514 166, 514 186, 514 169, 514 179, 514 17, 514 18

Abstract:

There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.