Jason Simon

US Patent:

6737519, May 18, 2004

Filed:

Jul 28, 2000

Appl. No.:

09/627465

Inventors:

Tim Keith - Bedford MA
Randall Little - Newtonville MA
Paul Van Eerdewegh - Weston MA
Richard Del Mastro - Norfolk MA
Jason Simon - Westfield NJ
Kristina Allen - Hopkinton MA
Sunil Pandit - Gaithersburg MD

Assignee:

Genome Therapeutics Corporation - Waltham MA

International Classification:

C07H 2104

US Classification:

536 231, 4353201, 435325, 435252, 435471, 435455, 236 243, 236 2431

Abstract:

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

US Patent:

7205146, Apr 17, 2007

Filed:

Oct 22, 2001

Appl. No.:

10/021698

Inventors:

Tim Keith - Bedford MA, US
Randall D. Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Josée Dupuis - Newton MA, US
Richard G. Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

C12N 5/10
C12N 15/70
C12N 1/20
C12N 1/00
C07H 21/04

US Classification:

435325, 536 235, 4353201, 435419, 4352521, 43525411

Abstract:

This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

US Patent:

7407804, Aug 5, 2008

Filed:

Dec 22, 2003

Appl. No.:

10/743704

Inventors:

Tim Keith - Bedford MA, US
Randall Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Josée Dupuis - Newton MA, US
Richard Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

C07H 21/02
C12N 1/20
C12N 15/00
C12N 5/02

US Classification:

435325, 4352523, 4353201, 435243, 536 231

Abstract:

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

US Patent:

7501118, Mar 10, 2009

Filed:

Sep 24, 2003

Appl. No.:

10/670184

Inventors:

Tim Keith - Bedford MA, US
Randall Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Josée Dupuis - Newton MA, US
Richard Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

A61K 39/395
A61K 39/44
C07K 16/18
C07K 17/00

US Classification:

4241301, 5303871, 5303879, 5303881, 53038824, 5303892, 5303911

Abstract:

This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

US Patent:

7928200, Apr 19, 2011

Filed:

Jul 25, 2008

Appl. No.:

12/180184

Inventors:

Tim Keith - Bedford MA, US
Randall Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Richard Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

C07K 16/00

US Classification:

5303871, 5303881, 5303911, 5303873

Abstract:

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

US Patent:

8105826, Jan 31, 2012

Filed:

Mar 23, 2007

Appl. No.:

11/690650

Inventors:

Tim Keith - Bedford MA, US
Randall D. Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Josée Dupuis - Newton MA, US
Richard G. Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil D. Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

C12N 5/10

US Classification:

435325, 4353201, 435419, 4352521, 43525411

Abstract:

This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.

US Patent:

8124734, Feb 28, 2012

Filed:

Apr 15, 2011

Appl. No.:

13/087480

Inventors:

Tim Keith - Bedford MA, US
Randall Little - Newtonville MA, US
Paul Van Eerdewegh - Weston MA, US
Richard Del Mastro - Norfolk MA, US
Jason Simon - Westfield NJ, US
Kristina Allen - Hopkinton MA, US
Sunil Pandit - Gaithersburg MD, US

Assignee:

Oscient Pharmaceuticals Corporation - Waltham MA

International Classification:

C07K 1/00

US Classification:

530350, 514 11, 514 17, 514 48, 514 49

Abstract:

This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

US Patent:

20030138925, Jul 24, 2003

Filed:

Apr 13, 2001

Appl. No.:

09/834597

Inventors:

Tim Keith - Bedford MA, US
RANDALL LITTLE - NEWTONVILLE MA, US
PAUL VAN EERDEWEGH - WESTON MA, US
JOSEE DUPUIS - NEWTON MA, US
RICHARD DEL MASTRO - NORFOLK MA, US
JASON SIMON - WESTFIELD NJ, US
KRISTINA ALLEN - HOPKINTON MA, US
SUNIL PANDIT - GAITHERSBURG MD, US

International Classification:

C12N009/00
C07H021/04
C12N001/18
C12N001/21
C12P021/02
C12N005/06

US Classification:

435/183000, 435/069100, 435/320100, 435/325000, 435/252300, 435/254200, 536/023200

Abstract:

This invention relates to genes identified from human chromosome 20p13-p12, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.