Jason David Thompson

US Patent:

20200315543, Oct 8, 2020

Filed:

Jun 22, 2020

Appl. No.:

16/907864

Inventors:

- Mountain View CA, US
Jason Donald Thompson - Palo Alto CA, US

International Classification:

A61B 5/00
A61B 5/0402
A61B 5/04
A61B 5/0295
A61B 8/08
A61B 5/026
A61B 5/11
A61B 5/024
A61B 8/00

Abstract:

A system for collecting data for assessment of cardiovascular function includes a plurality of monitoring devices coupled to different respective body parts. Each monitoring device is configured to measure a respective signal at the respective body part in response to cardiovascular activity. The respective signal includes a cardiovascular component attributable to the cardiovascular activity and an artifact component not attributable to the cardiovascular activity. When the monitoring devices measure the respective signals simultaneously over a same time period, the cardiovascular components are correlated, and the artifact components are not correlated. The system also includes a controller configured to: identify the cardiovascular components included in the signal measurements, according to the correlation of the cardiovascular components; reject the artifact components included in the signal measurements, according to the non-correlation of the artifact components; and determine cardiovascular information from the identified cardiovascular components for an assessment of cardiovascular function.

US Patent:

20200107760, Apr 9, 2020

Filed:

Dec 6, 2019

Appl. No.:

16/706098

Inventors:

- Mountain View CA, US
Eric Peeters - Mountain View CA, US
Vikram Singh Bajaj - Mountain View CA, US
Jason Thompson - Mountain View CA, US
Mark Askew - Mountain View CA, US

International Classification:

A61B 5/145
A61B 5/05
A61B 5/00

Abstract:

A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background signal.

US Patent:

20180214025, Aug 2, 2018

Filed:

Mar 29, 2018

Appl. No.:

15/939538

Inventors:

- Mountain View CA, US
Jason Donald Thompson - Palo Alto CA, US

International Classification:

A61B 5/00
A61B 5/026

Abstract:

Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

US Patent:

20180064352, Mar 8, 2018

Filed:

Nov 9, 2017

Appl. No.:

15/808555

Inventors:

- Mountain View CA, US
Jason D. Thompson - Palo Alto CA, US

International Classification:

A61B 5/026
A61B 5/00
A61B 5/1455

Abstract:

Systems are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with a coherent light source and detecting time-varying patterns of constructive and destructive interference in light received from portions of the biological tissue by an imager. The movement of blood cells and other light-scattering elements in the biological tissue causes transient, short-duration changes in light emitted from portions of the biological tissue proximate to the moving blood cells or other scatterers. High-frequency sampling or other high-bandwidth processing of light intensities detected by an imager could be used to determine the flow of blood or other fluids at a plurality of points in the biological tissue, to detect and/or localize a tumor in the biological tissue, to determine the location, pattern, width, or other properties of vasculature in the biological tissue, or to provide information for some other application(s).

US Patent:

20170357748, Dec 14, 2017

Filed:

Jun 8, 2016

Appl. No.:

15/177047

Inventors:

- Mountain View CA, US
Ian Peikon - Mountain View CA, US
Jason Thompson - Palo Alto CA, US
Tammo Spalink - Mountain View CA, US

International Classification:

G06F 19/12
G01N 35/00
C12Q 1/02
C12M 1/34
C12Q 3/00
C12M 1/36
G01N 33/50
C12M 1/00

Abstract:

The behavior and/or internal activities of a microorganism can be simulated using a model of the microorganism. Such simulations can be used to determine the efficacy of treatments, disinfectants, antibiotics, chemotherapies, or other methods of interacting with the microorganism, or to provide some other information about the microorganism. Systems and methods are provided herein for fitting, refining, or otherwise improving such models in an automated fashion. Such systems and methods include performing whole-cell experiments to determine a correspondence between the predictions of such models and the actual behavior of samples of the microorganism. Such systems and methods also include, based on such determined correspondences, directly assessing determined discrete sets of properties of the microorganism and/or of constituents of the microorganism and updating parameters of the model corresponding to the properties of the discrete set such that the overall accuracy of the model is improved.

US Patent:

20170288087, Oct 5, 2017

Filed:

Mar 29, 2016

Appl. No.:

15/083919

Inventors:

- Mountain View CA, US
Jason D. Thompson - Palo Alto CA, US
Michael Grundmann - San Jose CA, US

International Classification:

H01L 33/00
H01L 33/32

Abstract:

Embodiments regard micro-size devices formed by etch of sacrificial epitaxial layers. An embodiment of a method includes forming a plurality of epitaxial layers on a sapphire crystal, wherein the epitaxial layers include a buffer layer on the sapphire crystal, a sacrificial layer above the buffer layer, and one or more device layers above the sacrificial layer; etching to singulate the semiconductor devices, the etching being through the one or more device layers and wholly or partially through the sacrificial layer; electrochemical etching of the sacrificial layer; and lift-off of one or more semiconductor devices from the buffer layer.

US Patent:

20170196455, Jul 13, 2017

Filed:

Mar 27, 2017

Appl. No.:

15/469921

Inventors:

Andrew Homyk - Belmont CA, US
Mark West Askew - San Francisco CA, US
Jason Donald Thompson - Palo Alto CA, US

International Classification:

A61B 5/00

Abstract:

Wearable devices are described herein including at least two photodetectors and a mount configured to mount the at least two photodetectors to an external surface of a wearer. The at least two photodetectors are configured to detect alignment between the wearable device and a target on or in the body of the wearer (e.g., to detect the location of vasculature within the body of the wearer relative to the at least two photodetectors). Alignment of the at least two photodetectors relative to the target could enable detection of one or more physiological properties of the wearer. For example, the wearable device could include a sensor configured to detect a property of the target when the sensor is above the target, and alignment of the target relative to the at least two photodetectors could include the sensor being located above the target.

US Patent:

20170196492, Jul 13, 2017

Filed:

Mar 27, 2017

Appl. No.:

15/470102

Inventors:

- Mountain View CA, US
Eric Peeters - Mountain View CA, US
Vikram Singh Bajaj - Mountain View CA, US
Jason Thompson - Mountain View CA, US
Mark Askew - Mountain View CA, US

International Classification:

A61B 5/145
A61B 5/01
A61B 5/021
G06F 19/00
A61B 5/1455
G01R 33/24
G01R 33/44
A61B 5/00
A61B 5/024

Abstract:

A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.