Jason West

US Patent:

20050014134, Jan 20, 2005

Filed:

Mar 8, 2004

Appl. No.:

10/795549

Inventors:

Jason West - Castro Valley CA, US
James Stamps - Livermore CA, US
Isaac Shokair - Livermore CA, US
Ronald Renzi - Tracy CA, US
Victoria Vandernoot - Pleasanton CA, US
Boyd Wiedenman - Alpharetta GA, US
Todd Lane - Livermore CA, US
Julia Fruetel - Livermore CA, US

International Classification:

G01N033/53
C07K001/00
C12Q001/70
G01L001/20
B01D061/58
C25B007/00
C02F001/469
G01F001/64
G01N033/564
B01D061/42
B01D059/42
G01N027/26
G01L009/18
C07K001/26
C07K017/00

US Classification:

435005000, 435007100, 530350000, 435974000, 435975000, 436536000

Abstract:

The present invention provides systems and processes for the collection and identification of macromolecules, such as biologically-derived macromolecules (e.g., proteins and nucleic acids), by measuring and comparing the molecular weight signatures of macromolecular samples. Reproducible molecular weight signatures provides reliable sample identification. In the case of viruses, proteomic molecular weight signatures can be used for identifying viral agents.

US Patent:

20050095602, May 5, 2005

Filed:

Nov 4, 2003

Appl. No.:

10/701097

Inventors:

Jason West - Castro Valley CA, US
Timothy Shepodd - Livermore CA, US
Stewart Griffiths - Livermore CA, US
Ronald Renzi - Tracy CA, US
Boyd Wiedenman - Alpharetta GA, US

International Classification:

C12Q001/68
C12M001/34

US Classification:

435006000, 435287200, 435288500

Abstract:

Disclosed are microflulidic chips that include a plurality of vias; a functionalized porous polymer monolith capable of being in fluid communication with a via; a microarray capable of being in fluid communication with the functionalized porous polymer monolith; and an observation port through which at least one target disposed within the microarray is capable of being detected. The disclosed microfluidic chips contain microarrays that can be effectively coupled to functionalized porous polymer monoliths for capturing and concentrating sample nucleic acids. Also disclosed are microfluidic chips containing microarray probes having observation ports that enable the preparation of microarrays and the detection of targets. These microfluidic chips are capable of capturing and concentrating genetic material for the analysis and identification of biological organisms, such as so-called “threat genes” from chimeric bioweapons.

US Patent:

20070238090, Oct 11, 2007

Filed:

Apr 11, 2006

Appl. No.:

11/402656

Inventors:

Kyle W. Hukari - San Ramon CA, US
Jason A.A. West - Castro Valley CA, US

International Classification:

C12Q 1/00
C12M 3/00

US Classification:

435 4, 4352871

Abstract:

The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50 C.

US Patent:

20090305264, Dec 10, 2009

Filed:

Mar 2, 2007

Appl. No.:

12/296000

Inventors:

Jason A.A. West - Castro Valley CA, US
Brent C. Satterfield - Mesa AZ, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435 6, 536 243

Abstract:

The present invention provides inter alia, cooperative probe assays for analyzing and identifying biological substances.

US Patent:

20110014673, Jan 20, 2011

Filed:

Jul 14, 2010

Appl. No.:

12/835822

Inventors:

Kyle W. Hukari - Dublin CA, US
Jason A.A. West - Pleasanton CA, US

Assignee:

ARCXIS BIOTECHNOLOGIES - Pleasanton CA

International Classification:

C12N 13/00
C12N 5/00
C12M 1/02

US Classification:

4351731, 435325, 4353061

Abstract:

The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50 C.

US Patent:

20110294205, Dec 1, 2011

Filed:

Mar 23, 2011

Appl. No.:

13/069820

Inventors:

Kyle W. Hukari - Dublin CA, US
Jason A.A. West - Pleasanton CA, US
Michael A. Shultz - Bend OR, US
Richard Milson - Citrus Heights CA, US
Nikolas M. Isely - Moraga CA, US
Michael C. DeRenzi - San Ramon CA, US

International Classification:

C12M 1/12
C12N 5/071

US Classification:

435325, 4353061

Abstract:

Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.

US Patent:

20120128548, May 24, 2012

Filed:

Aug 8, 2008

Appl. No.:

12/673192

Inventors:

Jason A.A. West - Pleasanton CA, US
Jesse Thompson - Brentwood CA, US

Assignee:

ARCXIS Biotechnologies - Pleasanton CA

International Classification:

G01N 30/00
B29C 59/02
B29C 45/00
B32B 37/06
B29C 45/03
B29C 45/73
B01L 3/00
B05D 5/00

US Classification:

422430, 422502, 422 681, 264293, 427275, 427243, 1562722, 425542, 425547, 2643281

Abstract:

Provided are microfluidic devices and methods for fabricating and bonding such devices. Also provided are kits for analyzing analyte-containing samples and for lysing cells.

US Patent:

20130295602, Nov 7, 2013

Filed:

Feb 28, 2013

Appl. No.:

13/781307

Inventors:

Jake Kimball - Oakland CA, US
Myo Thu Maung - Brisbane CA, US
Andrew May - San Francisco CA, US
Michael C. Norris - Mountain View CA, US
Dominique G. Toppani - Oakland CA, US
Marc A. Unger - San Mateo CA, US
Jing Wang - Daly City CA, US
Jason A.A. West - Pleasanton CA, US

International Classification:

C12Q 1/68

US Classification:

435 34, 435174, 435 912

Abstract:

Methods, systems, and devices are described for multiple single-cell capturing and processing utilizing microfluidics. Tools and techniques are provided for capturing, partitioning, and/or manipulating individual cells from a larger population of cells along with generating genetic information and/or reactions related to each individual cell. Different capture configurations may be utilized to capture individual cells and then processing each individual cell in a multi-chamber reaction configuration. Some embodiments may provide for specific target amplification, whole genome amplification, whole transcriptome amplification, real-time PCR preparation, copy number variation, preamplification, mRNA sequencing, and/or haplotyping of the multiple individual cells that have been partitioned from the larger population of cells. Some embodiments may provide for other applications. Some embodiments may be configured for imaging the individual cells or associated reaction products as part of the processing. Reaction products may be harvested and/or further analyzed in some cases.