Jay M Matthews

US Patent:

6713475, Mar 30, 2004

Filed:

Jul 24, 2001

Appl. No.:

09/911605

Inventors:

William J. Hoekstra - Chapel Hill NC
Alexey B. Dyatkin - Lansdale PA
Bruce E. Maryanoff - Forest Grove PA
Jay M. Matthews - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3155

US Classification:

514220, 540497, 540559

Abstract:

The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

US Patent:

6765004, Jul 20, 2004

Filed:

Jun 12, 2000

Appl. No.:

09/592520

Inventors:

William J. Hoekstra - Chapel Hill NC
Michael N. Greco - Lansdale PA
Leonard R. Hecker - Harleysville PA
Bruce E. Maryanoff - Forest Grove PA
Jay M. Matthews - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3155

US Classification:

514215, 540577

Abstract:

The invention is directed to tricyclic indoloazepine compounds useful as vasopressin receptor antagonists, pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions involving increased vascular resistance and cardiac insufficiency which include hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis or water retention in a subject in need thereof.

US Patent:

7317005, Jan 8, 2008

Filed:

Feb 10, 2004

Appl. No.:

10/775675

Inventors:

William J. Hoekstra - Chapel Hill NC, US
Alexey B. Dyatkin - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Jay M. Matthews - Lansdale PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61P 9/00
A61K 31/55
C07D 487/00
C07D 513/00

US Classification:

514220, 540497, 540559

Abstract:

The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

US Patent:

7351857, Apr 1, 2008

Filed:

Jun 3, 2005

Appl. No.:

11/145119

Inventors:

Xiaoli Chen - Belle Mead NJ, US
Keith T. Demarest - Flemington NJ, US
Jung Lee - Ambler PA, US
Jay M. Matthews - Lansdale PA, US
Philip Rybczynski - Branchburg NJ, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07C 241/00
C07C 315/00
A01N 37/12

US Classification:

562439, 514562, 514563, 562428

Abstract:

The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.

US Patent:

7763605, Jul 27, 2010

Filed:

Oct 27, 2005

Appl. No.:

11/260118

Inventors:

Jay Matthews - Lansdale PA, US
Bruce Maryanoff - New Hope PA, US

Assignee:

Janssen Pharmaceutica, N.V.

International Classification:

A61P 9/00
A61K 31/55
C07D 243/14

US Classification:

514221, 540573

Abstract:

The invention is directed to novel [1,4]benzodiazepine compounds useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising [1,4]benzodiazepine compounds of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.

US Patent:

7897781, Mar 1, 2011

Filed:

May 9, 2007

Appl. No.:

11/746318

Inventors:

Raymond W. Colburn - Chalfont PA, US
Scott L. Dax - Landenberg PA, US
Christopher Flores - Lansdale PA, US
Jay Matthews - Lansdale PA, US
Ning Qin - Blue Bell PA, US
Laura Reany - Quakertown PA, US
Christopher Teleha - Fort Washington PA, US
Mark A. Youngman - North Wales PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

C07F 9/28

US Classification:

548113

Abstract:

The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

US Patent:

8143259, Mar 27, 2012

Filed:

Aug 11, 2009

Appl. No.:

12/539267

Inventors:

Raymond W. Colburn - Spring House PA, US
Scott L. Dax - Landenberg PA, US
Christopher M. Flores - Spring House PA, US
Donald W. Ludovici - Spring House PA, US
Jay M. Matthews - Spring House PA, US
Mingde Xia - Spring House PA, US
Xiaoqing Xu - Spring House PA, US
Mark A. Youngman - Spring House PA, US
Bin Zhu - Spring House PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

A61K 31/495
A61K 31/47
A61K 31/404
A61K 31/40
C07D 241/04
C07D 215/02
C07D 209/04
C07D 207/08

US Classification:

51425501, 514314, 514419, 514423, 544382, 546166, 548491, 548540

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:.

US Patent:

8153682, Apr 10, 2012

Filed:

Jul 18, 2008

Appl. No.:

12/175740

Inventors:

Shawn T. Branum - Raritan NJ, US
Raymond W. Colburn - Spring House PA, US
Scott L. Dax - Landenberg PA, US
Christopher M. Flores - Spring House PA, US
Michele C. Jetter - Norristown PA, US
Yi Liu - Spring House PA, US
Donald Ludovici - Spring House PA, US
Mark J. Macielag - Cranbury NJ, US
Jay M. Matthews - Spring House PA, US
James J. McNally - Spring House PA, US
Laura M. Reaney - Spring House PA, US
Ronald K. Russell - Raritan NJ, US
Ning Qin - Spring House PA, US
Christopher Teleha - Spring House PA, US
Kenneth M. Wells - Raritan NJ, US
Scott C. Youells - Spring House PA, US
Mark A. Youngman - Spring House PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

C07D 419/12
C07D 417/12
C07D 413/12
C07D 409/04
C07D 409/12
C07D 333/66
A61K 31/5377
A61K 31/496
A61K 31/4535
A61K 31/433
A61K 31/4245
A61K 31/422
A61K 31/4196
A61K 31/4192
A61K 31/4178
A61K 31/4025
A61K 31/381

US Classification:

514443, 514414, 514364, 514394, 514382, 514397, 514361, 514442, 51425213, 5142335, 514324, 5142282, 514360, 514384, 514374, 514406, 548454, 548131, 5483051, 548252, 5483114, 548129, 548525, 548122, 5482632, 548235, 548127, 5483644, 548143, 544376, 544146, 544 62, 546202, 549 57

Abstract:

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:.