Jean L Schmid from Rancho Palos Verdes, CA

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Author
Jean Schmid

ISBN #
2829000188

Tubulin Inhibitor And Process For Its Preparation
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US Patent:

7244736, Jul 17, 2007
Filed:

Jun 12, 2006
Appl. No.:

11/451078
Inventors:

David Michael Blum - Upper Saddle River NJ, US
Yanzhong Wu - Bardonia NY, US
Jean Schmid - Chester NY, US
Timothy John Doyle - Morristown NJ, US
Jay Thomas Afragola - Spring Valley NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/4965
C07D 403/00
US Classification:

51425505, 544295
Abstract:

The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making hemifumarate compounds and compositioning of the present invention.

Process For The Preparation Of Tubulin Inhibitors
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US Patent:

7396835, Jul 8, 2008
Filed:

Dec 8, 2004
Appl. No.:

11/007839
Inventors:

Yanzhong Wu - Bronx NY, US
Jean Schmid - Chester NY, US
Jay Thomas Afragola - Spring Valley NY, US
David Blum - Saddle River NJ, US
Assignee:

Wyeth - Madison NJ
International Classification:

A01N 43/90
A61K 31/519
C07D 487/00
US Classification:

51425931, 544263
Abstract:

The present invention provides a process for the preparation of 6-[(substituted)phenyl]-triazolopyrimidine dicarboxylic acid salt and as a hydrated salt having the structural formula (I).

Methods For Preparing Sulfonamide Compounds
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US Patent:

7476762, Jan 13, 2009
Filed:

Apr 19, 2007
Appl. No.:

11/788352
Inventors:

Asaf Ragim Alimardanov - Nanuet NY, US
Jean Schmid - Chester NY, US
Jay Thomas Afragola - Spring Valley NY, US
Gulnaz Khafizova - West Nyack NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07C 303/00
C07C 229/00
C07C 241/00
US Classification:

564 86, 560 34, 562439
Abstract:

Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided:.

Tubulin Inhibitor And Process For Its Preparation
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US Patent:

7501423, Mar 10, 2009
Filed:

Jun 4, 2007
Appl. No.:

11/810311
Inventors:

David Michael Blum - Upper Saddle River NJ, US
Yanzhong Wu - Bardonia NY, US
Jean Schmid - Chester NY, US
Timothy John Doyle - Morristown NJ, US
Jay Thomas Afragola - Spring Valley NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/4965
US Classification:

51425505
Abstract:

The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making said hemifumarate.

Process For Preparation Of Substituted Amino Alcohols
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US Patent:

7521552, Apr 21, 2009
Filed:

Dec 8, 2004
Appl. No.:

11/006936
Inventors:

Yanzhong Wu - Bronx NY, US
Arkadiy Rubezhov - West Nyack NY, US
Jean Schmid - Chester NY, US
Jay Thomas Afragola - Spring Valley NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07D 265/30
C07D 265/32
C07D 295/08
C07D 295/10
C07D 241/04
C07D 295/00
C07D 211/20
C07D 211/30
C07D 207/04
C07D 207/46
C07D 205/00
C07C 209/00
US Classification:

544170, 544400, 546248, 548571, 548950, 564481
Abstract:

There is provided a process for the preparation of substituted amino alcohols HO—(CH)—NRRfrom haloalcohols HO—(CH)—X, where X is Cl, Br or I, by reaction with an amine HNRR, in water as solvent at a temperature range of about 20 C. to about 90 C. optionally in the presence of a catalytic amount of an iodide source metal iodides. The haloalcohols are useful in the preparation of 6-[(substituted)phenyl]-triazolopyrimidine compounds which are useful in the treatment of cancer.

Process For Preparing Substituted Aryl Cycloalkanol Derivatives
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US Patent:

20070129377, Jun 7, 2007
Filed:

Dec 4, 2006
Appl. No.:

11/566415
Inventors:

Alexander Gontcharov - Rivervale NJ, US
Antonia Nikitenko - Tarrytown NY, US
Jean Schmid - Chester NY, US
John Potoski - West Nyack NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/495
C07D 241/04
US Classification:

514252120, 544400000
Abstract:

Processes are disclosed for preparing substituted aryl cycloalkanol derivatives, particularly chiral substituted aryl cycloalkanol derivatives of the general formula:

Methods For Preparing Sulfonamide Compounds
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US Patent:

20090082591, Mar 26, 2009
Filed:

Dec 8, 2008
Appl. No.:

12/330130
Inventors:

Asaf Ragim Alimardanov - Nanuet NY, US
Jean Schmid - Chester NY, US
Jay Thomas Afragola - Spring Valley NY, US
Gulnaz Khafizova - West Nyack NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07C 67/30
C07C 45/00
US Classification:

560227, 568488
Abstract:

Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided:or a pharmaceutically acceptable salt thereof, wherein, R-Rare defined herein. Also provided are methods for preparing compounds of the following structure:wherein, R, m, n, p, r, and s are defined herein.