Marie Iannone - Durham NC, US Kenneth Pearce - Durham NC, US Jean Shearin - Durham NC, US Catherine Simmons - Durham NC, US Daniel Svoboda - Durham NC, US Dana Vanderwall - Durham NC, US
International Classification:
G01N033/53
US Classification:
435/007100
Abstract:
A rapid method of characterizing interactions between compounds and biological molecules in vitro, in order to predict the in vivo characteristics of the compounds, is described. Preferably, the methods utilize labeled microspheres in multiplexed assays.
Antibodies To Cd23, Derivatives Thereof, And Their Therapeutic Uses
Jean-Yves Marcel Paul Bonnefoy - Le Sappey, FR James Scott Crowe - Stevenage, GB Jonathan Henry Ellis - Ware, GB Nicholas Timothy Rapson - Cambridge, GB Jean Shearin - Durham NC, US
Assignee:
Glaxo Wellcome Inc. - Research Triangle Park NC
International Classification:
C12P 21/08 C07K 16/28 A61K 39/395
US Classification:
4241431, 5303873, 5303881, 53038822
Abstract:
The invention relates to antibodies which bind to the CD23 (FCεRII) type II molecule particularly altered antibodies including antibodies which bind to the CD23 (FCεRII) type II molecule characterized by an affinity constant equal to or greater than 1×10Ka Mol, the preparation of such antibodies, pharmaceutical compositions which contain such antibodies and their use in therapy particularly in the treatment of autoimmune and inflammatory disorders.