Wallace T. Ashton - Clark NJ Louis Barash - Westfield NJ Jeannette E. Brown - Summit NJ Donald W. Graham - Mountainside NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D21370
US Classification:
424251
Abstract:
Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E. C. 3. 4. 13. 11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclo-propanecarboxamido)-. omega. -pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs).
Jeannette E. Brown - Summit NJ Edward F. Rogers - Middletown NJ Donald W. Graham - Mountainside NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C11C 100
US Classification:
260413
Abstract:
Traumatin, 12-oxo-trans (E) -10-docecenoic acid, is prepared from 10-oxomethyldecanoate by reaction with (triphenylphosphoranylene)acetaldehyde to form 12-oxomethyldodecenoate; blocking the 12-oxo group; hydrolyzing the ester group; and deblocking the 12-oxo group.