Jeff S Chen

US Patent:

5766154, Jun 16, 1998

Filed:

Sep 27, 1996

Appl. No.:

8/722788

Inventors:

Jay Wilson - Portola Valley CA
Shawn Hanna - Woodside CA
Jeff Chen - Mountain View CA
Robert C. Hall - Palo Alto CA
Teddy Bryant - San Francisco CA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

A61M 5178

US Classification:

604157

Abstract:

The present invention is directed to a vascular access device for introducing a catheter in a blood vessel using a guide advancing mechanism. The device generally comprises a housing, an introducer needle, a catheter, a guide wire and an actuating means. The introducer needle of the vascular access device is used to penetrate the blood vessel. The actuating means is then initiated and the guide wire is steadily propelled into the blood vessel. Once the guide wire is in place, the catheter, which is concentrically placed over the introducer needle and guide wire, is uncoupled from the vascular access device and guided into the blood vessel by the guide wire.

US Patent:

7646433, Jan 12, 2010

Filed:

May 31, 2005

Appl. No.:

11/142128

Inventors:

Jeff Chen - Irvine CA, US
William Chen - Taoyuan, TW

Assignee:

D-Link Systems, Inc. - Fountain Valley CA
Alpha Networks, Inc. - Hsinchu

International Classification:

H04N 5/50
G06F 3/00

US Classification:

348581, 715800

Abstract:

Disclosed are a system and method of processing image data for presentation of an image on a display. In particular, image data may be transformed and/or mapped for presentation on a display based, at least in part, on a user preference.

US Patent:

7704995, Apr 27, 2010

Filed:

May 2, 2003

Appl. No.:

10/513081

Inventors:

Chris A. Buhr - Redwood City CA, US
Sunghoon Ma - Foster City CA, US
Zerom Tesfai - Castro Valley CA, US
Longcheng Wang - Palo Alto CA, US
Erick Wang Co - Redwood City CA, US
Sergey Epshteyn - Fremont CA, US
Abigail R Kennedy - San Leandro CA, US
Baili Chen - Palo Alto CA, US
Larisa Dubenko - San Francisco CA, US
Neel Kumar Anand - San Mateo CA, US
Tsze H. Tsang - El Cerrito CA, US
John M. Nuss - Danville CA, US
Csaba J Peto - Alameda CA, US
Kenneth D. Rice - Mill Valley CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Kevin Luke Schnepp - Elk Grove CA, US
Xian Shi - San Francisco CA, US
James William Leahy - San Leandro CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Timothy Patrick Forsyth - San Mateo CA, US
Tai Phat Huynh - Oakland CA, US
Grace Mann - Brisbane CA, US
Larry Wayne Mann - Redwood City CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Peter Lamb - Oakland CA, US
David J. Matthews - San Francisco CA, US
Nicole Miller - San Francisco CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

C07D 279/16
C07D 279/12
C07D 417/12
C07D 265/36
C07D 413/12
C07D 403/12
C07D 401/12
C07D 405/12
C07D 409/12
C07D 411/12
C07D 419/12
C07D 241/18
C07D 241/20
A61K 31/55
A61K 31/497
A61K 31/5355
A61K 31/541
C07D 305/12
C07D 307/79
A61K 31/44
A61P 35/00

US Classification:

51421705, 51425211, 51425213, 51425505, 51425506, 5142358, 5142278, 5142305, 514352, 544405, 544407, 544295, 544120, 544 586, 544 60, 544105, 540598, 549310, 546309, 546311

Abstract:

This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.

US Patent:

8026237, Sep 27, 2011

Filed:

Jul 30, 2005

Appl. No.:

11/572962

Inventors:

Lynne Canne Bannen - Pacifica CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Brenton T Flatt - Poway CA, US
Timothy Patrick Forsyth - Hayward CA, US
Xiao-Hui Gu - San Diego CA, US
Morrison B Mac - San Francisco CA, US
Larry W Mann - Richland MI, US
Grace Mann - Brisbane CA, US
Richard Martin - San Diego CA, US
Raju Mohan - Encinitas CA, US
Brett Murphy - Lake Elsinore CA, US
Michael Charles Nyman - San Diego CA, US
William C Stevens - Escondido CA, US
Yong Wang - Foster City CA, US
Jason H Wu - San Diego CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/40
A61K 31/4439
A61K 31/454
A61K 31/5377
A61K 31/506
C07D 207/34
C07D 403/02
C07D 413/02

US Classification:

5142355, 514256, 514423, 514326, 514343, 544333, 544141, 548537, 548465

Abstract:

Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

US Patent:

8067436, Nov 29, 2011

Filed:

May 24, 2007

Appl. No.:

11/753514

Inventors:

Lynne Canne Bannen - Pacifica CA, US
Diva Sze-Ming Chan - San Francisco CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Leandro CA, US
Timothy Patrick Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
Vasu Jammalamadaka - Pleasanton CA, US
Richard George Khoury - Redwood City CA, US
James William Leahy - San Leandro CA, US
Morrisson B. Mac - San Francisco CA, US
Grace Mann - Brisbane CA, US
Larry W. Mann - Richland MI, US
John M. Nuss - Danville CA, US
Jason Jevious Parks - Sacramento CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Yong Wang - Forster City CA, US
Wie Xu - Danville CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/47
A61K 31/4709
A61K 31/517
A61K 31/5377

US Classification:

514312, 546153, 544119, 544287, 544363, 544128, 5142345, 5142352, 51425217, 51425307, 5142662, 51426622, 5142663

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

US Patent:

8088767, Jan 3, 2012

Filed:

Sep 28, 2007

Appl. No.:

12/443103

Inventors:

Adam Antoni Galan - Alameda CA, US
Jeff Chen - San Francisco CA, US
Hongwang Du - Millbrae CA, US
Timothy Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Patrick Kearney - San Francisco CA, US
James W. Leahy - San Leandro CA, US
Matthew Sangyup Lee - San Francisco CA, US
Grace Mann - San Mateo CA, US
Brian Hugh Ridgway - Belmont CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Peiwen Zhou - Palo Alto CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/5377
A61K 31/4439
A61K 31/4184
C07D 413/14
C07D 401/14
C07D 403/12

US Classification:

5142345, 514338, 514395, 544139, 5462734, 5483061

Abstract:

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

US Patent:

8178570, May 15, 2012

Filed:

Apr 8, 2004

Appl. No.:

10/552424

Inventors:

Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
James William Leahy - San Leandro CA, US
Brian Hugh Ridgway - Belmont CA, US
Grace Mann - Brisbane CA, US
Larry W. Mann - Richland MI, US
Craig Stacy Takeuchi - Burlingame CA, US
Joan C. Sangalang - Mountain View CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A01N 43/64
A01N 43/54
A61K 31/41
C07D 239/42
C07D 401/04
C07D 249/08

US Classification:

514383, 514256, 5482622

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

US Patent:

8211929, Jul 3, 2012

Filed:

Dec 28, 2005

Appl. No.:

11/722719

Inventors:

Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple Meyr - San Leandro CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
James W. Leahy - San Leandro CA, US
Gary Lee Lewis - San Francisco CA, US
Grace Mann - Brisbane CA, US
Larry W. Mann - Richland MI, US
Robin Tammie Noguchi - San Bruno CA, US
Brian Hugh Ridgway - Belmont CA, US
Joan Cruz Sangalang - San Francisco CA, US
Kevin Luke Schnepp - Elk Grove CA, US
Xian Shi - San Bruno CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Matthew Alan Williams - San Mateo CA, US
John Nuss - Danville CA, US
Atwood K. Cheung - Arlington MA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A01N 43/56
A61K 31/415
C07D 239/02
C07D 231/00

US Classification:

514403, 514247, 514256, 514378, 544242, 544297, 544322, 548240

Abstract:

The invention provides compounds and methods for inhibition of kinases, more specifically IGF 1 R kinases. The invention also provides compounds and methods for inhibition of wildtype Abl. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, wherein, V is NRR, or O—R, wherein X is H, halo, C-Calkyl, NO, mono-, di-, or tri-halo substituted methyl, NRR,. C(O)O—C-Calkyl, or N(R)—C(O)—C-Calkyl; Y is H, halo, OH, C-Calkyl, C-Calkyl-NR,R, NRR,, C-Calkoxy, —N(R)—(CH)NRR, —C(O)O—C-Calkyl, —O—(CH)—NRR, —C(O)—C-Calkyl, —C-C-alkyl-R, —O—R, —C(O)—R, —O—(CH)—R, —C(O)—NRR, —C(O)—N(R)-aryl, —C(O)—N(R)(CH)—NRR, —C(O)—N(R)—(CH)-aryl —C(O)—N(R)—(CH)-heterocyclyl; or X and Y together with the atoms to which they are attached form a 4-7 membered heterocyclyl or heteroaryl group containing one or two heteroatoms independently selected from O, N, and S.