Jeffery Lane Carter

US Patent:

6492390, Dec 10, 2002

Filed:

May 24, 2001

Appl. No.:

09/865177

Inventors:

Jeffery S Carter - Chesterfield MO
Mark G Obukowicz - Kirkwood MO
Balekudru Devadas - Chesterfield MO
John J Talley - St. Louis MO
David L Brown - Chesterfield MO
Matthew J Graneto - Chesterfield MO
Stephen R Bertenshaw - Cheshire CT
Srinivasan Raj Nagarajan - Chesterfield MO
Cathleen E Hanau - St. Louis MO
Susan J Hartmann - Kirkwood MO
Cindy L Ludwig - St. Louis MO
Suzanne Metz - Chesterfield MO
Donald E Korte - Mundelein IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 3138

US Classification:

514311, 514432, 514456, 514569, 546170, 549 57, 549405, 562490

Abstract:

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula Iâ wherein X, A , A , A , A , R, Râ, R and R are as described in the specification.

US Patent:

6613790, Sep 2, 2003

Filed:

Apr 16, 2002

Appl. No.:

10/123730

Inventors:

Jeffery S. Carter - Chesterfield MO

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

A61K 31415

US Classification:

514406, 5483771

Abstract:

A compound of Formula (I), or a pharmaceutically-acceptable salt thereof, suitable for use in the treatment of a cyclooxygenase-2 mediated disease is provided. Also provided is a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically-acceptable salt thereof, and a method for treatment of a cyclooxygenase-2 mediated disease by administering to a subject in need thereof a therapeutically-effective amount of the pharmaceutical composition.

US Patent:

6806288, Oct 19, 2004

Filed:

Feb 2, 2000

Appl. No.:

09/496695

Inventors:

Jeffery S Carter - Chesterfield MO
Mark G Obukowicz - Kirkwood MO
Balekudru Devadas - Chesterfield MO
John J Talley - St. Louis MO
David L Brown - Chesterfield MO
Matthew J Graneto - Chesterfield MO
Stephen R Bertenshaw - Cheshire CT
Srinivasan Raj Nagarajan - Chesterfield MO
Cathleen E Hanau - Chesterfield MO
Susan J Hartman - Kirkwood MO
Cindy L Ludwig - St. Louis MO
Suzanne Metz - Chesterfield MO
Donald E Korte - Mundelein IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 31385

US Classification:

514434, 549 23

Abstract:

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula Iâ wherein X, A , A , A , A , R, Râ, R and R are as described in the specification.

US Patent:

6809111, Oct 26, 2004

Filed:

May 15, 2003

Appl. No.:

10/439023

Inventors:

Jeffery S. Carter - Chesterfield MO

Assignee:

Pharmacia Corporation - Chesterfield MO

International Classification:

A61K 3142

US Classification:

514378, 548247

Abstract:

A compound of Formula (I), or a pharmaceutically-acceptable salt thereof, suitable for use in the treatment of a cyclooxygenase-2 mediated disease is provided. Also provided is a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically-acceptable salt thereof, and a method for treatment of a cyclooxygenase-2 mediated disease by administering to a subject in need thereof a therapeutically-effective amount of the pharmaceutical composition.

US Patent:

7109211, Sep 19, 2006

Filed:

Aug 19, 2004

Appl. No.:

10/922036

Inventors:

Jeffery S Carter - Chesterfield MO, US
Mark G Obukowicz - Kirkwood MO, US
Balekudru Devadas - Chesterfield MO, US
John J Talley - St. Louis MO, US
David L Brown - Chesterfield MO, US
Matthew J Graneto - Chesterfield MO, US
Stephen R Bertenshaw - Cheshire CT, US
Srinivasan Raj Nagarajan - Chesterfield MO, US
Cathleen E Hanau - Chesterfield MO, US
Susan J Hartmann - Kirkwood MO, US
Cindy L Ludwig - St. Louis MO, US
Suzanne Metz - Chesterfield MO, US
Donald E Korte - Mundelein IL, US

Assignee:

Pharmacia Corporation (of Pfizer, Inc.) - Chesterfield MO

International Classification:

A61K 31/47
C07D 211/30

US Classification:

514311, 546169, 546170

Abstract:

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′.

US Patent:

7138411, Nov 21, 2006

Filed:

Nov 22, 2002

Appl. No.:

10/303150

Inventors:

Jeffery S Carter - Chesterfield MO, US
Mark G Obukowicz - Kirkwood MO, US
Balekudru Devadas - Chesterfield MO, US
John J Talley - St. Louis MO, US
David L Brown - Chesterfield MO, US
Matthew J Graneto - Chesterfield MO, US
Stephen R Bertenshaw - Cheshire CT, US
Srinivasan Raj Nagarajan - Chesterfield MO, US
Cathleen E Hanau - St. Louis MO, US
Susan J Hartmann - Kirkwood MO, US
Cindy L Ludwig - St. Louis MO, US
Suzanne Metz - Chesterfield MO, US
Donald E Korte - Mundelein IL, US

Assignee:

G.D. Searle & Co. - St. Louis MO

International Classification:

A61K 31/47
A61K 31/38
A61K 31/35
C07D 307/77
C07D 335/04

US Classification:

514311, 514432, 514456, 514569, 549456, 549 23, 549 57, 562490, 546156

Abstract:

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′.

US Patent:

20050032852, Feb 10, 2005

Filed:

Sep 14, 2004

Appl. No.:

10/940053

Inventors:

Jeffery Carter - Chesterfield MO, US

International Classification:

C07D213/55
C07D207/46
A61K031/18
A61K031/44

US Classification:

514357000, 514408000, 514602000, 564086000, 546335000, 548577000

Abstract:

A compound of Formula (I), or a pharmaceutically-acceptable salt thereof, suitable for use in the treatment of a cyclooxygenase-2 mediated disease is provided. Also provided is a pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically-acceptable salt thereof, and a method for treatment of a cyclooxygenase-2 mediated disease by administering to a subject in need thereof a therapeutically-effective amount of the pharmaceutical composition.

US Patent:

20050131028, Jun 16, 2005

Filed:

Sep 9, 2004

Appl. No.:

10/936875

Inventors:

Jeffery Carter - Chesterfield MO, US
Bernard Hummel - Kalamazoo MI, US

Assignee:

Pharmacia Corporation - Chesterfield MO

International Classification:

A61K031/4439
A61K031/44
A61K031/4152
A61K031/365

US Classification:

514341000, 514357000, 514406000, 514471000

Abstract:

A method is disclosed for providing extended duration treatment or prevention of pain, inflammation and inflammation-related disorders in a subject in need of such extended duration treatment or prevention by administering to the subject a Cox-2 selective inhibitor having certain added substituent groups. Also disclosed is a method for extending the duration of the plasma half-life of diaryl-substituted Cox-2 selective inhibitors by substituting halogen, haloalkyl, haloalkoxy, alkyl, nitrile, cyano or alkoxy groups at certain positions on the diaryl-substituted rings of the inhibitor molecule. A novel composition comprising such extended duration Cox-2 selective inhibitors is also disclosed.