Jeffrey D Allen

US Patent:

20030134294, Jul 17, 2003

Filed:

May 21, 2002

Appl. No.:

10/153131

Inventors:

Andrew Sandford - Marlborough MA, US
Venkiteswaran Subramanian - San Diego CA, US
Jeffrey Allen - Poway CA, US
Paul Swanson - San Diego CA, US
Joey Storer - Midland MI, US
Deepak Sharma - Midland MI, US

International Classification:

C12Q001/68
G01N033/53
C08G018/00
A61K009/14

US Classification:

435/006000, 435/007100, 527/301000, 527/204000, 424/486000

Abstract:

A biologic can be immobilized in a transparent polyurethane-hydrogel composition. Such a polyurethane-hydrogel composition can be prepared from forming a polyurethane-hydrogel mixture and immobilizing a biologic in the mixture. The mixture can be formed by admixing a prepolymer and a water-soluble crosslinker in aqueous solvent and in the substantial absence of organic solvent. A suitable prepolymer generally includes at least one water-soluble polyol and at least one isocyanate and can be added to the mixture in an amount of no greater than about 5 weight percent based on total weight of all components. A suitable crosslinker generally has a crosslinker functionality of at least 2. A biologic includes cells, peptides, nucleics, peptide nucleic acids, saccharides, lipopolysaccharides, glycolipids, and combinations of these. A polyurethane-hydrogel composition having an immobilized biologic can be particularly useful for biomedical applications. Some examples of useful biomedical applications include protein microarrays, cell microarrays, and DNA microarrays.

US Patent:

20050147994, Jul 7, 2005

Filed:

Nov 1, 2004

Appl. No.:

10/979012

Inventors:

Andrew Sandford - Marlborough MA, US
Venkiteswaran Subramanian - San Diego CA, US
Jeffrey Allen - Poway CA, US
Paul Swanson - San Diego CA, US
Joey Storer - Midland MI, US
Deepak Sharma - Midland MI, US

International Classification:

C12Q001/68
G01N033/53

US Classification:

435006000, 435007100, 525054100

Abstract:

A biologic can be immobilized in a transparent polyurethane-hydrogel composition. Such a polyurethane-hydrogel composition can be prepared from forming a polyurethane-hydrogel mixture and immobilizing a biologic in the mixture. The mixture can be formed by admixing a prepolymer and a water-soluble crosslinker in aqueous solvent and in the substantial absence of organic solvent. A suitable prepolymer generally includes at least one water-soluble polyol and at least one isocyanate and can be added to the mixture in an amount of no greater than about 5 weight percent based on total weight of all components. A suitable crosslinker generally has a crosslinker functionality of at least 2. A biologic includes cells, peptides, nucleics, peptide nucleic acids, saccharides, lipopolysaccharides, glycolipids, and combinations of these. A polyurethane-hydrogel composition having an immobilized biologic can be particularly useful for biomedical applications. Some examples of useful biomedical applications include protein microarrays, cell microarrays, and DNA microarrays.

US Patent:

20210242945, Aug 5, 2021

Filed:

Apr 26, 2021

Appl. No.:

17/240034

Inventors:

- Lowell MA, US
Jeffrey Allen - Lowell MA, US

International Classification:

H04B 10/69
H04L 25/03
H04B 10/25

Abstract:

A system and method for controlling optical receiver operation in response to a received optic signal power level that includes providing an optic signal receiver having operation determined by one or more system settings. During operation, the optic signal is received and converted to an electrical signal. The electrical signal is evaluated to determine a power level of the electrical signal. Responsive to the power level of the electrical signal exceeding a first predetermined threshold, adjusting a first system setting and responsive to the power level of the received electrical signal decreasing below a second predetermined threshold, adjusting the first system setting. Then, responsive to the power level of the received electrical signal exceeding a third predetermined threshold, adjusting a second system setting and responsive to the power level of the received electrical signal decreasing below a fourth predetermined threshold, adjusting the second system setting.

US Patent:

20200162169, May 21, 2020

Filed:

Nov 19, 2019

Appl. No.:

16/688998

Inventors:

- Lowell MA, US
Jeffrey Allen - Lowell MA, US

International Classification:

H04B 10/69
H04B 10/25
H04L 25/03

Abstract:

A system and method for controlling optical receiver operation in response to a received optic signal power level that includes providing an optic signal receiver having operation determined by one or more system settings. During operation, the optic signal is received and converted to an electrical signal. The electrical signal is evaluated to determine a power level of the electrical signal. Responsive to the power level of the electrical signal exceeding a first predetermined threshold, adjusting a first system setting and responsive to the power level of the received electrical signal decreasing below a second predetermined threshold, adjusting the first system setting. Then, responsive to the power level of the received electrical signal exceeding a third predetermined threshold, adjusting a second system setting and responsive to the power level of the received electrical signal decreasing below a fourth predetermined threshold, adjusting the second system setting.