Jeffrey K Chen

US Patent:

6427688, Aug 6, 2002

Filed:

Feb 1, 2000

Appl. No.:

09/495494

Inventors:

Michael Ligotke - San Diego CA
Andrew W. Gieschen - San Diego CA
Robert F. Eisele - San Diego CA
Thomas R. Jackson - San Diego CA
Jeffrey Chen - Seattle WA
Bernard Greenspan - San Diego CA
Clyde Witham - San Diego CA
Gary Ward - San Diego CA

Assignee:

Dura Pharmaceuticals, Icn. - San Diego CA

International Classification:

A61M 1500

US Classification:

12820315, 12820312, 12820323

Abstract:

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

US Patent:

6715486, Apr 6, 2004

Filed:

Jan 31, 2001

Appl. No.:

09/773261

Inventors:

Andrew W. Gieschen - San Diego CA
Michael Ligotke - San Diego CA
Jeffrey Chen - San Diego CA
Charles Ganem - San Diego CA
Bernard Greenspan - San Diego CA

Assignee:

Quadrant Technologies Limited - Nottingham

International Classification:

A61M 1600

US Classification:

12820315, 12820312, 604 58

Abstract:

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from the larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater air flow and powder dispersion, without any increased effort by the patient.

US Patent:

6971384, Dec 6, 2005

Filed:

Feb 19, 2004

Appl. No.:

10/782449

Inventors:

Andrew W. Gieschen - San Diego CA, US
Michael Ligotke - San Diego CA, US
Jeffrey Chen - San Diego CA, US
Charles Ganem - San Diego CA, US
Bernard Greenspan - San Diego CA, US

Assignee:

Quadrant Technologies Limited - Nottingham

International Classification:

A61M015/00

US Classification:

12820315, 12820312, 604 58

Abstract:

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.

US Patent:

7958890, Jun 14, 2011

Filed:

Dec 4, 2008

Appl. No.:

12/328657

Inventors:

Andrew W. Gieschen - San Diego CA, US
Michael Ligotke - San Diego CA, US
Jeffrey Chen - San Diego CA, US
Charles F. Ganem - San Diego CA, US
Bernard Greenspan - San Diego CA, US

Assignee:

Quadrant Technologies Limited

International Classification:

A61M 15/00
A61M 16/00

US Classification:

12820315, 12820314, 12820319, 12820322, 12820323, 12820012

Abstract:

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.

US Patent:

7981694, Jul 19, 2011

Filed:

Jan 28, 2004

Appl. No.:

10/767251

Inventors:

Gerry R. Boss - La Jolla CA, US
Stephen B. Jones - San Diego CA, US
Jeffrey C. Chen - San Gabriel CA, US
Friederike von Lintig - San Diego CA, US
Stephanie Hoffman - Patatuma CA, US
Adam Kimmerly - San Diego CA, US
Joann Luu - San Jose CA, US
Matthew Christopher Mycroft - Sierra Madre CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 33/543

US Classification:

436518, 436524, 436527, 436528, 436532

Abstract:

The invention is a method for the isolation of molecules of interest using tubes in which at least a portion of the inner walls of the tube are coated with microbeads that are coated with a capture reagent to bind the molecule of interest. The microbeads may be glass or polymer beads. The invention is a method and apparatus for preparation of the tubes for use in the method of the invention. The invention is a method for determining ratios of guanine nucleotides bound to guanine-nucleotide binding proteins.

US Patent:

20060005833, Jan 12, 2006

Filed:

Sep 12, 2005

Appl. No.:

11/224406

Inventors:

Andrew Gieschen - San Diego CA, US
Michael Ligotke - San Diego CA, US
Jeffrey Chen - San Diego CA, US
Charles Ganem - San Diego CA, US
Bernard Greenspan - San Diego CA, US

International Classification:

A61M 15/00
A61M 16/00

US Classification:

128203150

Abstract:

A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.

US Patent:

60067470, Dec 28, 1999

Filed:

Mar 20, 1997

Appl. No.:

8/821753

Inventors:

Robert Eisele - San Diego CA
Karen Davies - San Diego CA
Jeffrey Chen - San Diego CA
Bernard Greenspan - San Diego CA

Assignee:

Dura Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61M 1500
A61M 1508

US Classification:

12820315

Abstract:

A dry powder inhaler has a lid pivotally attached to an inhaler housing. A medicine containing cartridge is attached to the top of the housing and includes a cartridge ring with apertures for holding dry powdered medicine. A slide-groove assembly located on the underside of the lid advances the cartridge ring to a next aperture when a user first opens, then closes the lid. A venturi air passageway assembly is contained within the housing of the dry powdered inhaler. The venturi air passageway assembly includes a tapered inlet section, a throat section, and a tapered outlet section. A pressure switch is advantageously located within the housing for actuating the mixing process within the mixing chamber. During inhalation, the pressure switch contained within the housing actuates the motor driven impeller within the mixing chamber of the inhaler when the pressure within the venturi air passageway reaches a predetermined level. The pressure at which the pressure switch closes corresponds to a specifically calibrated inhalation flow rate.

US Patent:

62730851, Aug 14, 2001

Filed:

Jan 5, 1999

Appl. No.:

9/226054

Inventors:

Robert Eisele - San Diego CA
Karen Davies - San Diego CA
Jeffrey Chen - San Diego CA
Bernard Greenspan - San Diego CA

Assignee:

Dura Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61M 1500

US Classification:

12820315

Abstract:

A dry powder inhaler has a lid pivotally attached to an inhaler housing. A medicine containing cartridge is attached to the top of the housing and includes a cartridge ring with apertures for holding dry powdered medicine. A slide-groove assembly located on the underside of the lid advances the cartridge ring to a next aperture when a user first opens, then closes the lid. A venturi air passageway assembly is contained within the housing of the dry powdered inhaler. The venturi air passageway assembly includes a tapered inlet section, a throat section, and a tapered outlet section. A pressure switch is advantageously located within the housing for actuating the mixing process within the mixing chamber. During inhalation, the pressure switch contained within the housing actuates the motor driven impeller within the mixing chamber of the inhaler when the pressure within the venturi air passageway reaches a predetermined level. The pressure at which the pressure switch closes corresponds to a specifically calibrated inhalation flow rate.