Jeffrey E Davidson

US Patent:

20150165053, Jun 18, 2015

Filed:

Aug 10, 2013

Appl. No.:

13/964062

Inventors:

Mylisa Parette - Bellefonte PA, US
Danielle Asquino - Philipsburg PA, US
Kari Eyer - Sinking Spring PA, US
James Adair - State College PA, US
Jeffrey Davidson - Boalsburg PA, US
Mark Kester - Harrisburg PA, US

International Classification:

A61K 47/48
A61K 31/7105
A61K 9/14
A61K 31/713

Abstract:

Stable, non-toxic, calcium phosphate nanoparticles are formed that incorporate one or more oligonucleotides. RNAi nucleotides may be incorporated and, in particular, siRNA nucleotides. Since the siRNA nanoparticles dissociate leaving only naturally occurring residual materials, calcium and phosphate, along with the siRNA, they are particularly useful as carrier vehicles. The ability to incorporate more than one siRNA provides a means to block or knock down the translation of multiple targeted proteins at the same time.