Jeffrey M Davidson

US Patent:

6383478, May 7, 2002

Filed:

Apr 21, 2000

Appl. No.:

09/556743

Inventors:

Ales Prokop - Nashville TN
Mikhail M. Dikov - Nashville TN
Phillip Williams - Lebanon TN
Jeffrey M. Davidson - Nashville TN

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A61K 3174

US Classification:

424 7808

Abstract:

The present invention provides a convenient polymeric film or microparticulate vehicle to deliver protein factors into appropriate body sites to induce appropriate therapeutic effects. It also improves the existing methodologies for immunoisolation of non-human pancreatic islets (via microencapsulation) to protects them from the immunologically-different host. This invention demonstrates how vascularization and angiogenesis can be induced by means of addition of proper angiogenic factors. The angiogenesis is sustained over a long period of time, depending on the release characteristics of the polymeric matrix. Three-dimensional polymeric structures (mesh or perforated tubing and film) are used as resident materials for microcapsules bearing islets. Blood capillaries are generated outside the capsules and penetrate through the implant openings to ingrow into the vicinity of capsules/islets.

US Patent:

20040136961, Jul 15, 2004

Filed:

Jun 30, 2003

Appl. No.:

10/609722

Inventors:

Ales Prokop - Nashville TN, US
Jeffrey Davidson - Nashville TN, US
Gianluca Carlesso - Nashville TN, US
Derya Unutmaz - Nashville TN, US

International Classification:

A61K048/00

US Classification:

424/093200

Abstract:

The present invention provides compositions comprising a water-based core solution and a water-based corona solution surrounding the core solution. The compositions comprise polyanionic polymers and salts and polycationic polymers and cations and is useful for adenoviral delivery of a gene or delivery of another drug. The compositions may be nanoparticulate, microcapsular or form a polymeric sheet. Also provided are methods of use for the compositions.

US Patent:

20050008572, Jan 13, 2005

Filed:

Apr 28, 2004

Appl. No.:

10/833370

Inventors:

Ales Prokop - Nashville TN, US
Jeffrey Davidson - Nashville TN, US
Gianluca Carlesso - Nashville TN, US
David Roberts - Bethesda MD, US

International Classification:

A61K009/14
A61K049/00

US Classification:

424009600, 424489000

Abstract:

The present invention provides a series of biocompatible, nanoparticulate formulations that are designed to retain and deliver peptides such as anti-angiogenic factors over an extended time course. The nanoparticles can be targeted to a cell or tissue by targeting ligands crosslinked or conjugated to the corona of the nanoparticles. In addition to selective targeting, the nanoparticles also may perform noninvasive imaging using bioluminescence and/or magnetic resonance imaging via a contrast agent in the core of the nanoparticle. Also provided are methods of delivering to and, optionally, imaging of a cell or tissue. Furthermore, methods of producing the nanoparticles in batch or continous mode via simple mixing or micromixing.

US Patent:

20050266090, Dec 1, 2005

Filed:

May 10, 2005

Appl. No.:

11/125438

Inventors:

Ales Prokop - Nashville TN, US
Jeffrey Davidson - Nashville TN, US
Gianluca Carlesso - Nashville TN, US
David Roberts - Bethesda MD, US

International Classification:

A61K009/14

US Classification:

424489000

Abstract:

The present invention provides biocompatible, low molecular weight nanoparticulate formulations that are designed to retain and deliver therapeutics over an extended time course. The therapeutic may be conjugated or adsorbed to the periphery of the corona or conjugated to a core polymer. The nanoparticles comprise targeting ligands also conjugated or adsorbed to the periphery of the corona and/or a contrast agent in the core of the nanoparticle. As such, methods of selective targeting and/or methods of noninvasive imaging using bioluminescence and/or magnetic resonance imaging. Also provided are methods of delivering to and, optionally, imaging of a cell or tissue. Further provided are methods of producing the nanoparticles in batch or continuous mode via simple mixing or laminar flow.

US Patent:

61036951, Aug 15, 2000

Filed:

Oct 13, 1999

Appl. No.:

9/416869

Inventors:

Kirk B. Lane - Brentwood TN
Richard Light - Brentwood TN
Jeffrey M. Davidson - Nashville TN

Assignee:

Vanderbilt University - Nashville TN

International Classification:

A61K 3800

US Classification:

514 12

Abstract:

The present invention provides a method of producing a pleurodesis in a mammal, comprising introducing a therapeutically effective dose of a pharmaceutical composition comprising TGF. beta. into the pleural cavity.

US Patent:

46109935, Sep 9, 1986

Filed:

Aug 8, 1984

Appl. No.:

6/638808

Inventors:

John H. Wedig - Guilford CT
John G. Babish - Ithaca NY
Jeffrey Davidson - Tulare CA

Assignee:

Olin Corporation - Cheshire CT

International Classification:

A61K 3144

US Classification:

514335

Abstract:

Described is a method for treating an animal for bovine mastitis wherein said animal is administered an effective amount of at least one selected pyridine-N-oxide disulfide compound to treat or prevent bovine mastitis.

US Patent:

44016662, Aug 30, 1983

Filed:

Feb 1, 1982

Appl. No.:

6/344666

Inventors:

John H. Wedig - Guilford CT
John G. Babish - Ithaca NY
Jeffrey Davidson - Tulare CA

Assignee:

Olin Corporation - New Haven CT

International Classification:

A61K 31555
A61K 3144

US Classification:

424245

Abstract:

Described is a method for treating an animal for bovine mastitis wherein said animal is administered an effective amount of at least one metallic salt of pyridine-2-thione-N-oxide to treat or prevent bovine mastitis.

US Patent:

20190003941, Jan 3, 2019

Filed:

Jan 17, 2017

Appl. No.:

16/064151

Inventors:

- Nashville TN, US
- Washington DC, US
Jeffrey M. Davidson - Nashville TN, US
Stephen R. Koch - Madison TN, US
Veniamin Yu Sidorov - Nashville TN, US

International Classification:

G01N 3/20
G02B 21/26
G02B 21/08
G02B 21/36

Abstract:

A device for measuring a tension of a bio-object construct as it is being stretched that includes a microscope, a holding member for accommodating the bio-object, and a probe. The microscope includes a condenser, an objective and a stage positioned therebetween. The stage is movable along a horizontal plane. The holding member is fixable on the stage. The probe has a first end attached to the condenser, and a second end placed in the holding member. The stage operably moves such that the bio-object construct moves toward the second end of the probe and contacts with the second end of the probe, thereby causing a displacement of the second end of the probe and a displacement of the bio-object construct, which are used to measure the tension of the bio-object construct.