Jeffrey D Field

US Patent:

20220233535, Jul 28, 2022

Filed:

Apr 26, 2020

Appl. No.:

17/608981

Inventors:

- Washington DC, US
Shannon M. White - Arlington VA, US
Jeffrey Field - Philadelphia PA, US

International Classification:

A61K 31/506
A61K 31/409
A61K 31/4725
A61K 31/137
A61K 31/427
A61K 31/407
A61K 31/4745
A61K 38/48
A61K 31/519
A61K 31/4523
A61K 31/4184
A61K 31/18
A61P 35/00

Abstract:

Methods of treating or preventing cancer, or treating or preventing noncancerous tumors or lesions, in a subject in need thereof. The methods involve administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject. In addition, methods of inhibiting or preventing glycolysis in cancer cells in a subject, promoting mitochondrial respiration in cancer cells in a subject, and promoting oxidative stress in cancer cells in a subject, by administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject.