Jeffrey L Huntington

US Patent:

57668396, Jun 16, 1998

Filed:

Mar 19, 1996

Appl. No.:

8/618529

Inventors:

Jay M. Johnson - Dayton OH
Jeffrey L. Huntington - Yellow Springs OH

Assignee:

YSI Incorporated - Yellow Springs OH

International Classification:

C12Q 100
G01N 2726

US Classification:

435 4

Abstract:

Methods for forming thin layer barrier layer films for use in enzyme containing laminated membranes and membranes formed thereby are disclosed. The barrier layers exhibit improved acetaminophen rejection and comprise a cellulose acetate/cellulose acetate butyrate blend. The thin layer barrier membranes are formed from a plural solvent containing solution and are cured at a critical temperature of about 102. degree. -114. degree. F. , most preferably at about 106. degree. F. -114. degree. F. while traveling through a circulating hot air oven. Alternatively, the membranes can be cured at room temperature or in a stagnant oven at temperatures of from room temperature to about 175. degree. C. (350. degree. F. ) for a period of from about 10 minutes to 1 hour.