Jeffrey S Link

US Patent:

8049005, Nov 1, 2011

Filed:

Mar 31, 2010

Appl. No.:

12/751383

Inventors:

Jean-Marc Lapierre - Pelham NH, US
Nivedita Namdev - Westford MA, US
Jeffrey S. Link - Londonderry NH, US

Assignee:

ArQule, Inc. - Woburn MA

International Classification:

C07D 345/00
A61K 31/33

US Classification:

540 1, 514183

Abstract:

The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

US Patent:

8293892, Oct 23, 2012

Filed:

Sep 23, 2011

Appl. No.:

13/241523

Inventors:

Jean-Marc Lapierre - Pelham NH, US
Nivedita Namdev - Westford MA, US
Jeffrey S. Link - Londonderry NH, US

Assignee:

ArQule, Inc. - Woburn MA

International Classification:

C07D 345/00
A61K 31/33

US Classification:

540 1, 514183

Abstract:

The present invention relates to substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted tetrahydropyrazolo-pyrido-azepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

US Patent:

8470812, Jun 25, 2013

Filed:

Dec 29, 2010

Appl. No.:

12/981120

Inventors:

Jeffrey S. Link - Londonderry NH, US

Assignee:

ArQule, Inc. - Woburn MA

International Classification:

A61K 31/551
C07D 487/12
A61P 35/00

US Classification:

514219, 540555, 424400, 424405, 514247, 514359, 514381

Abstract:

The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

US Patent:

8541407, Sep 24, 2013

Filed:

Mar 31, 2011

Appl. No.:

13/076695

Inventors:

Syed M. Ali - North Andover MA, US
Mark A. Ashwell - Carlisle MA, US
Eugene Kelleher - Wellesley MA, US
Steffi Koerner - Medford MA, US
Jean-Marc Lapierre - Pelham NH, US
Jeffrey S. Link - Londonderry NH, US
Yanbin Liu - Acton MA, US
Magdi Moussa - Malden MA, US
Rocio Palma - North Andover MA, US
Manish Tandon - Framingham MA, US
David Vensel - Boston MA, US
Neil Westlund - Groton MA, US
Hui Wu - Malden MA, US

Assignee:

ArQule, Inc. - Woburn MA

International Classification:

C07D 487/14

US Classification:

514219, 540555

Abstract:

The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

US Patent:

20150305536, Oct 29, 2015

Filed:

Apr 23, 2014

Appl. No.:

14/120072

Inventors:

Jeffrey S. Link - Verona VA, US
Paula O. Link - Verona VA, US

International Classification:

A47G 25/80

Abstract:

A combination boot jack, boot tray and boot rack for the removal, cleaning, movement and storage of mud boots, muck boots, galoshes, snow boots, work boots and similar rubber boots. The boot tray is broad enough for a user to step into the top surface of its base with both booted feet. The invention has a pair of U-shaped notches elevated above the top surface of the base, as well as an open-back/closed toe foot box, built into the boot tray. The user may thus step into the boot tray, use the pair of U-shaped notches as a boot jack to grip and secure the heels of both boots at once, and remove them, one at a time. During removal of the second boot, the user's unbooted foot is placed into the protected foot box, keeping it dry and out of contact with the ground, the outside of the boots, or any part of the boot jack and boot tray touched or soiled by the boots during their removal. Further, the boot jack and boot tray may be used as a boot rack for moving a pair of boots from place to place without touching them, as well as for later cleaning or storage.