Jeffrey F Lowrie from South Easton, MA, age 63

Us Patents

Cyclic Amine Bace-1 Inhibitors Having A Benzamide Substituent
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US Patent:

7662816, Feb 16, 2010
Filed:

Aug 4, 2004
Appl. No.:

10/910987
Inventors:

Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Andrew Stamford - Chatham Township NJ, US
Corey Strickland - Martinsville NJ, US
Johannes H. Voigt - Union NJ, US
Yusheng Wu - New York NY, US
Ying Huang - East Brunswick NJ, US
Yan Xia - Edison PA, US
Samuel Chackalamannil - Califon NJ, US
Tao Guo - Dayton NJ, US
Douglas W. Hobbs - Yardley PA, US
Thuy X. H. Le - Monmouth Junction NJ, US
Jeffrey F. Lowrie - Pennington NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Assignee:

Schering Corporation - Kenilworth NJ
International Classification:

A61K 31/496
C07D 401/12
C07D 401/14
C07D 403/12
C07D 409/12
C07D 211/34
C07D 207/16
C07D 207/26
C07D 243/08
C07D 413/12
US Classification:

5142358, 51425213, 51425309, 51425313, 51425405, 51425502, 514218, 514326, 514327, 514422, 514424, 540575, 544121, 544357, 544365, 544369, 544370, 544372, 544383, 544384, 544129, 544130, 546187, 546208, 546221, 546234, 548518, 548550, 548556
Abstract:

Disclosed are compounds of the formulaAlso disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.

Cyclic Amine Bace-1 Inhibitors Having A Benzamide Substituent
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US Patent:

8278334, Oct 2, 2012
Filed:

Dec 18, 2009
Appl. No.:

12/641952
Inventors:

Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Andrew Stamford - Chatham Township NJ, US
Corey Strickland - Martinsville NJ, US
Johannes H. Voigt - Union NJ, US
Yusheng Wu - New York NY, US
Ying Huang - East Brunswick NJ, US
Yan Xia - Edison PA, US
Samuel Chackalamannil - Califon NJ, US
Tao Guo - Dayton NJ, US
Douglas W. Hobbs - Yardley PA, US
Thuy X. H. Le - Monmouth Junction NJ, US
Jeffrey F. Lowrie - Pennington NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Assignee:

Merck, Sharp & Dohme Corp. - Rahway NJ
International Classification:

A61K 31/4439
A61K 31/40
A61K 31/4025
C07D 207/12
C07D 401/06
C07D 403/12
US Classification:

514340, 514422, 514424, 5462764, 5462784, 548518, 548556
Abstract:

Disclosed are compounds of the formulaAlso disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.

Cyclic Amine Bace-1 Inhibitors Having A Benzamide Substituent
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US Patent:

8623867, Jan 7, 2014
Filed:

Sep 11, 2012
Appl. No.:

13/610162
Inventors:

Jared N. Cumming - Garwood NJ, US
Ulrich Iserloh - Hoboken NJ, US
Andrew Stamford - Chatham NJ, US
Corey Strickland - Martinsville NJ, US
Johannes H. Voight - Cranford NJ, US
Yusheng Wu - New York NY, US
Ying Huang - Berkeley Heights NJ, US
Yan Xia - Edison NJ, US
Samuel Chackalamannil - Califon NJ, US
Tao Guo - Dayton NJ, US
Douglas W. Hobbs - Chesterfield MO, US
Thuy X. H. Le - Monmouth Junciton NJ, US
Jeffrey H. Lowrie - Pennington NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Pennington NJ, US
Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Pharmacopeia Drug Discovery, Inc. - Princeton NJ
International Classification:

A61K 31/445
A61K 31/4458
A61K 31/454
A61K 31/4545
A61K 31/5377
C07D 295/027
C07D 401/06
C07D 401/12
C07D 413/12
US Classification:

5142372, 514318, 514326, 514327, 514331, 544130, 546208, 546217, 546221, 546194
Abstract:

Disclosed are compounds of the formulaRisR is —C(O)—N(R)(R) orAlso disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.

Cyclic Amine Bace-1 Inhibitors Having A Heterocyclic Substituent
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US Patent:

20050043290, Feb 24, 2005
Filed:

Aug 4, 2004
Appl. No.:

10/911030
Inventors:

Jared Cumming - Garwood NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Ulrich Iserloh - Hoboken NJ, US
Andrew Stamford - Chatham Township NJ, US
Corey Strickland - Martinsville NJ, US
Johannes Voigt - Union NJ, US
Yusheng Wu - New York NY, US
Jianping Pan - Monmouth Junction NJ, US
Tao Guo - Dayton NJ, US
Douglas Hobbs - Yardley PA, US
Thuy Le - Monmouth Junction NJ, US
Jeffrey Lowrie - Pennington NJ, US
International Classification:

A61K031/55
C07D043/02
US Classification:

514210200, 514217050, 514217040, 514217060, 514217090, 540597000, 540601000
Abstract:

Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein

Cyclic Amine Bace-1 Inhibitors Having A Heterocyclic Substituent
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US Patent:

20090312341, Dec 17, 2009
Filed:

Jun 24, 2009
Appl. No.:

12/490884
Inventors:

Jared N. Cumming - Garwood NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Ulrich Iserloh - Hoboken NJ, US
Andrew Stamford - Chatham Township NJ, US
Corey Strickland - Martinsville NJ, US
Johannes H. Voigt - Cranford NJ, US
Yusheng Wu - New York NY, US
Jianping Pan - Monmouth Junction NJ, US
Tao Guo - Dayton NJ, US
Douglas W. Hobbs - Chesterfield MO, US
Thuy X. H. Le - Monmouth Junction NJ, US
Jeffrey F. Lowrie - Pennington NJ, US
International Classification:

A61K 31/496
C12N 9/99
A61P 25/28
US Classification:

51425214, 435184, 51425401, 51425405
Abstract:

Disclosed are novel compounds of the formulaor a pharmaceutically acceptable salt or solvate thereof, whereinAlso disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.

Context-Aware Virtual Keyboard For Chemical Structure Drawing Applications
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US Patent:

20200035334, Jan 30, 2020
Filed:

Oct 1, 2019
Appl. No.:

16/589341
Inventors:

- Waltham MA, US
Michael Wilson - Norton MA, US
Jeffrey F. Lowrie - South Easton MA, US
International Classification:

G16C 20/80
G16C 20/70
G06F 3/0488
G06F 3/0484
Abstract:

Described herein are systems, methods, and apparatus for electronically drawing and editing representations of chemical structures using an intuitive user interface. This user interface, the context-aware virtual keyboard, makes it faster and easier to draw and edit chemical structure representations by guiding the user through the sequence of steps required to produce the representation in a context-based, non-linear fashion. The context-based virtual keyboard allows a user to quickly create graphical representations of complex chemical structures by using the structure itself as a basis for presenting efficient options for subsequent drawing/editing steps. Different possible and/or likely actions (e.g., edits to a chemical structure being drawn) are presented to the user based on a selected navigation position on the drawing. Thus, a user can efficiently and intuitively modify a chemical structure drawing without the tedious manual selection of portions of the chemical structure and without searching through complicated menus.

Context-Aware Virtual Keyboard For Chemical Structure Drawing Applications
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US Patent:

20190236244, Aug 1, 2019
Filed:

Jan 30, 2018
Appl. No.:

15/884191
Inventors:

- Waltham MA, US
Michael Wilson - Norton MA, US
Jeffrey F. Lowrie - South Easton MA, US
International Classification:

G06F 19/00
G06F 3/0488
G06F 3/0484
Abstract:

Described herein are systems, methods, and apparatus for electronically drawing and editing representations of chemical structures using an intuitive user interface. This user interface, the context-aware virtual keyboard, makes it faster and easier to draw and edit chemical structure representations by guiding the user through the sequence of steps required to produce the representation in a context-based, non-linear fashion. The context-based virtual keyboard allows a user to quickly create graphical representations of complex chemical structures by using the structure itself as a basis for presenting efficient options for subsequent drawing/editing steps. Different possible and/or likely actions (e.g., edits to a chemical structure being drawn) are presented to the user based on a selected navigation position on the drawing. Thus, a user can efficiently and intuitively modify a chemical structure drawing without the tedious manual selection of portions of the chemical structure and without searching through complicated menus.

Cyclic Amide Bace-1 Inhibitors Having A Benzamide Substituent
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US Patent:

20140128361, May 8, 2014
Filed:

Jan 6, 2014
Appl. No.:

14/148703
Inventors:

- Princeton NJ, US
- Rahway NJ, US
Andrew Stamford - Chatham NJ, US
Corey Strickland - Martinsville NJ, US
Johannes H. Voight - Cranford NJ, US
Yusheng Wu - New York NY, US
Ying Huang - Berkeley Heights NJ, US
Yan Xia - Edison NJ, US
Samuel Chackalamannil - Califon NJ, US
Tao Guo - Dayton NJ, US
Douglas W. Hobbs - Chesterfield MO, US
Thuy X.H. Le - Monmouth Junction NJ, US
Jeffrey H. Lowrie - Pennington NJ, US
Kurt W. Salonz - Cranford NJ, US
Suresh D. Babu - Pennington NJ, US
Assignee:

Pharmacopeia Drug Discovery, Inc. - Princeton NJ
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:

C07D 243/08
C07D 233/32
C07D 205/04
US Classification:

51421001, 548950, 5483241, 514386, 540492, 514218
Abstract:

Disclosed are compounds of the formulaor a pharmaceutically acceptable salt or solvate thereof, whereinRisR is —C(O)—N(R)(R) orand the remaining variables are as defined in the specification.Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.