Jeffrey W Loy

US Patent:

20040121947, Jun 24, 2004

Filed:

Oct 23, 2002

Appl. No.:

10/281092

Inventors:

Arun Ghosh - River Forest IL, US
Jordan Tang - Edmond OK, US
Geoffrey Bilcer - Oklahoma City OK, US
Wanpin Chang - Edmond OK, US
Lin Hong - Oklahoma City OK, US
Gerald Koelsch - Oklahoma City OK, US
Jeffrey Loy - Norman OK, US
Robert Turner - Oklahoma City OK, US

International Classification:

A61K038/16
C07K014/00

US Classification:

514/012000, 514/007000, 530/350000

Abstract:

Compounds inhibit memapsin 2 -secretase activity and selectively inhibit memapsin 2 -secretase activity relative to memapsin 1 -secretase activity. The compounds are employed in methods to inhibit memapsin 2 -secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a -secretase site of a amyloid precursor protein and to decrease -amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.