Jeffrey A Miner

US Patent:

8648116, Feb 11, 2014

Filed:

Jul 28, 2008

Appl. No.:

12/671287

Inventors:

Jean-Michel Vernier - Laguna Niguel CA, US
Colin Edward Rowlings - Encinitas CA, US
Jean-Luc Girardet - Aliso Viejo CA, US
Stuart Dimock - Lake Forest CA, US
Barry Quart - Encinitas CA, US
Jeffrey N. Miner - San Diego CA, US

Assignee:

Ardea Biosciences, Inc. - San Diego CA

International Classification:

A61K 31/185
C07C 311/00

US Classification:

514602, 514601, 564 84, 564 80

Abstract:

This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.

US Patent:

53664710, Nov 22, 1994

Filed:

Oct 26, 1993

Appl. No.:

8/143446

Inventors:

Richard G. Jones - West Chester PA
Jeffrey A. Miner - Sanford MI

Assignee:

Pilling Co. - Fort Washington PA

International Classification:

A61M 2900

US Classification:

606191

Abstract:

An esophageal dilator comprises a hollow, flexible tube filled with a dispersion of Tungsten particles in a fluid silicone material for treating cardiospasm, esophagitis, stenosis and other esophageal diseases.