Jeffrey L Nelson

US Patent:

6475253, Nov 5, 2002

Filed:

Feb 26, 1999

Appl. No.:

09/242989

Inventors:

Scott R. Culler - Burnsville MN
John J. Gagliardi - Hudson WI
Thomas W. Larkey - Hugo MN
Eric G. Larson - Lake Elmo MN
Larry L. Martin - Maplewood MN
Jeffrey W. Nelson - Bayport MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B24D 334

US Classification:

51295, 51297, 51298, 428323

Abstract:

This invention pertains to a coated, bonded or non-woven abrasive article containing precisely shaped particles and a binder. These precisely shaped particles can contain abrasive grits, fillers, grinding aids and lubricants. The binder is preferably a mixture of a resole phenolic resin and a free radical curable resin, resulting in improved cutting and life span. Also disclosed is a method of forming the coated, bonded or non-woven abrasive article.

US Patent:

6521004, Feb 18, 2003

Filed:

Oct 16, 2000

Appl. No.:

09/688444

Inventors:

Scott R. Culler - Burnsville MN
James L. McArdle - Stillwater MN
Jeffrey W. Nelson - Bayport MN
John T. Wallace - Mendota Heights MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C09K 314

US Classification:

51298, 51307, 51308, 51309, 51293, 23313 R, 264117, 264460, 264461, 264462, 264638

Abstract:

A method for making abrasive agglomerate particles from a composition comprising at least a radiation curable binder and solid particulates. The method comprises the steps of forcing the composition through a perforated substrate to form agglomerate precursor particles which then separate from the perforated substrate. Then, the particles are irradiated to form soldified, handleable agglomerate particles before being collected.

US Patent:

6620214, Sep 16, 2003

Filed:

Oct 5, 2001

Appl. No.:

09/972316

Inventors:

James L. McArdle - Stillwater MN
Jeffrey W. Nelson - Bayport MN
Scott R. Culler - Burnsville MN
John T. Wallace - Mendota Heights MN

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

C09K 314

US Classification:

51298, 51307, 51308, 51309, 51293, 23313 R, 264118, 264460, 264461, 264462, 264464, 264463, 264470, 264472, 264476, 264477, 264638, 264639, 264655

Abstract:

Methods for making ceramic aggregate particles comprising forming a plurality of ceramic aggregate precursor particles from a composition by forcing the composition through at least one orifice in a substrate, at least partially curing the ceramic aggregate precursor particles, and heating the ceramic aggregate precursor particles to provide ceramic aggregate particles wherein solid particulates are bonded together by ceramic binder. In another aspect, the present invention provides methods for making an abrasive article utilizing methods for making abrasive ceramic aggregate particles comprising forming a plurality of ceramic aggregate precursor particles by passing a composition through at least one orifice in a substrate, separating the abrasive ceramic aggregate precursor particles from the substrate, at least partially curing the abrasive ceramic aggregate precursor particles, heating the abrasive ceramic aggregate precursor particles to provide abrasive ceramic aggregate particles bonded together by ceramic binder, and combining at least a portion of the abrasive ceramic aggregate particles with abrasive article binder material and abrasive material, with or without another abrasive material, to provide an abrasive article.

US Patent:

6664388, Dec 16, 2003

Filed:

Mar 4, 2002

Appl. No.:

10/091231

Inventors:

Jeffrey S. Nelson - Woodinville WA

Assignee:

Applera Corporation - Foster City CA

International Classification:

C07H 2104

US Classification:

536 2531, 536 2532, 536 2533, 536 2534, 536 254, 536 273, 536 281, 536 291

Abstract:

The present invention provides a process for the removal of protecting groups, i. e. deprotection, from chemically synthesized oligonucleotides. In one embodiment, the invention provides reagents suitable for use in such a process, and kits incorporating such reagents in a convenient, ready-to-use format. By use of the process and reagents of the invention, side-reactions leading to certain impurities that contaminate the synthesized oligonucleotides can be minimized. Methods and reagents are provided for deprotection of an oligonucleotide by reacting a protected oligonucleotide with a deprotection reagent wherein the deprotection reagent comprises an active methylene compound and an amine reagent. The active methylene compound has the structure: where substituent EWG is an electron-withdrawing group and R is hydrogen, C -C alkyl, C -C aryl, heterocycle or an electron-withdrawing group.

US Patent:

6913824, Jul 5, 2005

Filed:

Jul 2, 2003

Appl. No.:

10/612999

Inventors:

Scott R. Culler - Burnsville MN, US
James L. McArdle - Stillwater MN, US
Jeffrey W. Nelson - Bayport MN, US
John T. Wallace - Mendota Heights MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B29C009/06
B29C047/00
B29C070/00
D02G003/00

US Classification:

428401, 264 10, 264 13, 264115, 264118, 264405, 264470, 264482

Abstract:

A method for making agglomerate particles from a composition comprising at least a radiation curable binder and solid particulates. The method comprises the steps of forcing the composition through a perforated substrate to form agglomerate precursor particles which then separate from the perforated substrate. Then, the particles are irradiated to form soldified, handleable agglomerate particles before being collected.

US Patent:

7661247, Feb 16, 2010

Filed:

Jun 30, 2005

Appl. No.:

11/171525

Inventors:

Mark G. Schwabel - Lake Elmo MN, US
Jeffrey W. Nelson - Bayport MN, US
Joseph A. Scheller - Carlos MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN

International Classification:

B65B 53/00

US Classification:

53472, 5362661, 536285, 5361334, 5361392

Abstract:

A system for packaging resin bonded molded abrasive articles having a flexible package comprising at least one sidewall defining an enclosed volume and at least one resin bonded abrasive article positioned within the enclosed volume. The sidewall comprises a multilayer barrier composite having a water vapor transmission rate that is less than 0. 5 grams per 645 square centimeters (100 square inches) per 24 hours.

US Patent:

20040191808, Sep 30, 2004

Filed:

Dec 16, 2003

Appl. No.:

10/737059

Inventors:

Jeffrey Nelson - Woodinville WA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/025300

Abstract:

The present invention provides a process for the removal of protecting groups, i.e. deprotection, from chemically synthesized oligonucleotides. In one embodiment, the invention provides reagents suitable for use in such a process, and kits incorporating such reagents in a convenient, ready-to-use format. By use of the process and reagents of the invention, side-reactions leading to certain impurities that contaminate the synthesized oligonucleotides can be minimized. Methods and reagents are provided for deprotection of an oligonucleotide by reacting a protected oligonucleotide with a deprotection reagent wherein the deprotection reagent comprises an active methylene compound and an amine reagent. The active methylene compound has the structure: where substituent EWG is an electron-withdrawing group and R is hydrogen, C-Calkyl, C-Caryl, heterocycle or an electron-withdrawing group.

US Patent:

20050069928, Mar 31, 2005

Filed:

Aug 3, 2004

Appl. No.:

10/911239

Inventors:

Jeffrey Nelson - Woodinville WA, US
John Mulligan - Seattle WA, US
John Tabone - Bothell WA, US

Assignee:

Blue Heron Biotechnology, Inc. - Bothell WA

International Classification:

C12Q001/68
C07H021/04
C12P019/34
A61K048/00

US Classification:

435006000, 514044000, 435091200, 536025300

Abstract:

Disclosed is a significantly improved synthetic method of producing a set of mutagenized progeny polynucleotides which contain at least one substituted codon encoding for each of the 20 naturally encoded amino acids or any selected subset thereof. This in turn, similarly provides a method for producing from a parental template polypeptide, a set of mutagenized progeny polypeptides in which all 20 naturally encoded amino acids is represented at each original amino acid position or any selected subset thereof. The methods described herein enable the synthesis of defined, complex mixtures of oligonucleotides, in instances where the incorporation of degenerate bases is impractical. These oligonucleotide mixtures are useful for a variety of applications such as recombination methods, site-saturation mutagenesis, or the like.