Jeffrey G Randall

US Patent:

20210131966, May 6, 2021

Filed:

Jul 30, 2018

Appl. No.:

16/633488

Inventors:

- Somerville MA, US
Giles P. Blaney - Wenham MA, US
Akim Lennhoff - Cambridge MA, US
Jeffrey D. Randall - Cambridge MA, US
Harald Quintus-Bosz - Sudbury MA, US
Stuart E. Schechter - Newton MA, US
Kenneth A. Ritsher - Lowell MA, US
Hooman Hosseinkhannazer - Edmonton, CA
Graham McKinnon - Edmonton, CA

International Classification:

G01N 21/64

Abstract:

The present application discloses a sensor system that includes a sensor having a sensor surface, a sample cartridge including one or more flexible membranes and a membrane frame, the membrane frame including one or more openings covered by the one or more flexible membranes defining one or more wells for holding one or more samples, the flexible membrane having a sample side supporting the sample and an opposite sensor side, the sample cartridge being removably insertable in the sensor system such that the sensor side of the flexible membrane is positioned above and faces the sensor surface, a displacement mechanism that can be actuated to displace the flexible membrane toward the sensor surface such that the sample is moved to a position closer to the sensor surface, and an optical imaging system that detects light emitted from the sensor. Disclosed also are a cartridge cassette and a method of use.