Jeffrey Y Rubin

US Patent:

6420531, Jul 16, 2002

Filed:

May 31, 1995

Appl. No.:

08/455620

Inventors:

Jeffrey S. Rubin - Rockville MD
Paul W. Finch - Bethesda MD
Stuart A. Aaronson - Great Falls VA

Assignee:

The United States as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07K 14475

US Classification:

530399, 530395, 930 10, 435 694, 435243, 435325

Abstract:

Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

US Patent:

6479255, Nov 12, 2002

Filed:

May 29, 1998

Appl. No.:

09/087031

Inventors:

Jeffrey S. Rubin - Rockville MD
Paul Finch - Croton NY
Stuart Aaronson - New York NY
Xi He - Brighton MA

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

C12P 2106

US Classification:

435 691, 536 235, 530350, 4353201, 4352523, 435 6

Abstract:

The invention provides a novel, secreted protein that contains a region homologous to ligand binding domain of a cytokine receptor. This protein, called Frizzled-related protein (FRP), antagonizes the signaling of the Wnt family of cytokines. Extracellular signaling molecules such as the Wnt family members have essential roles as inducers of cellular proliferation, migration, differentiation, and tissue morphogenesis. As Wnt molecules are known to participate in the aberrant growth associated with neoplasia, Wnt antagonists such as FRP are valuable tools which both for understanding oncogenesis and for the design of new cancer therapies.

US Patent:

6566098, May 20, 2003

Filed:

Jun 7, 1995

Appl. No.:

08/484841

Inventors:

Andrew M. L. Chan - Rockville MD
Jeffrey S. Rubin - Rockville MD
Donald P. Bottaro - Kensington MD
Stuart A. Aaronson - New York City NY

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12N 1518

US Classification:

435 694, 4353201, 435325, 4352523, 536 2351

Abstract:

The present invention relates to a novel truncated forms of hepatocyte growth factor (HGF) which specifically antagonizes the activity of HGF and to a novel truncated form of HGF that is a partial HGF agonist. In particular, the present invention relates to the purification, molecular cloning, recombinant expression of the truncated HGF variants and related pharmaceutical compositions. The present invention further relates to the utilization of the small HGF variants to either inhibit HGF mitogenesis or stimulate HGF mitogenesis in cells expressing the receptor for HGF.

US Patent:

6600018, Jul 29, 2003

Filed:

Apr 10, 2000

Appl. No.:

09/546043

Inventors:

Jeffrey S. Rubin - Rockville MD
Susan Cumberledge - Amherst MA
Frieda Reichsman - Amherst MA
Aykut Uren - Baltimore MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07K 1400

US Classification:

530350, 530300, 530402, 514 2, 435 71, 435 691, 4353251, 4353201, 4241921, 536 231, 536 234

Abstract:

The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.

US Patent:

6709842, Mar 23, 2004

Filed:

Jun 7, 1995

Appl. No.:

08/477982

Inventors:

Jeffrey S. Rubin - Rockville MD
Paul W. Finch - Bethesda MD
Stuart A. Aaronson - Great Falls VA

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12N 121

US Classification:

435 694, 435 697, 435 711, 435358, 435365, 4352523, 4352528, 4352542, 4353201, 536 234, 536 2551, 530399

Abstract:

Disccoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

US Patent:

6833132, Dec 21, 2004

Filed:

May 31, 1995

Appl. No.:

08/455975

Inventors:

Jeffrey S. Rubin - Rockville MD
Paul W. Finch - Bethesda MD
Stuart A. Aaronson - Great Falls VA

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 3818

US Classification:

4241451, 4241391, 4241411, 514 2, 514 12, 514 21, 530399, 5303871, 5303879, 5303881, 53038824

Abstract:

Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

US Patent:

7026291, Apr 11, 2006

Filed:

Jun 7, 1995

Appl. No.:

08/477983

Inventors:

Jeffrey S. Rubin - Potomac MD, US
Paul W. Finch - Croton-on-Hudson NY, US
Stuart A. Aaronson - New York NY, US

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 38/18
C07K 14/475
C07K 14/50

US Classification:

514 12, 514 2, 530350, 530399

Abstract:

Discoveries are disclosed that show particular aspects of recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as production of antibodies. Means are described for determining the level of expression of genes for the KGF protein, for example, by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.

US Patent:

7036114, Apr 25, 2006

Filed:

Mar 29, 2002

Appl. No.:

10/113005

Inventors:

Thomas M. McWilliams - Menlo Park CA, US
Jeffrey B. Rubin - Pleasanton CA, US
Derek E. Pappas - Union City CA, US
Oyekunle A. Olukotun - Stanford CA, US
Jeffrey M. Broughton - Palo Alto CA, US
David R. Emberson - Santa Cruz CA, US
William kwei-cheung Lam - Newark CA, US
Liang T. Chen - Saratoga CA, US
Ihao Chen - San Jose CA, US
Earl T. Cohen - Fremont CA, US
Michael W. Parkin - Palo Alto CA, US

Assignee:

Sun Microsystems, Inc. - Santa Clara CA

International Classification:

G06F 9/45

US Classification:

717149, 717136, 719152

Abstract:

A computer system for cycle-based computation includes a processor array, a translation component adapted to translate a cycle-based design, a host computer operatively connected to the processor array and to the translation component, a data connection component interconnecting a plurality of members of the processor array using static routing, a synchronization component enabling known timing relationships among the plurality of members of the processor array, a host service request component adapted to send a host service request from a member of the processor array to the host computer, and an access component adapted to access a portion of a state of the processor array and a portion of a state of the data connection.