Jeffrey M Schubert

US Patent:

20130084346, Apr 4, 2013

Filed:

Feb 28, 2011

Appl. No.:

13/582601

Inventors:

Scott Wolkenberg - Wyndmoor PA, US
James C. Barrow - Arnold MD, US
Michael S. Poslusney - Nashville TN, US
Scott T. Harrison - Glenside PA, US
B. Wesley Trotter - Medfield MA, US
James Mulhearn - Elkins Park PA, US
Kausik K. Nanda - Norristown PA, US
Peter J. Manley - Harleysville PA, US
Zhijian Zhao - Wilmington DE, US
Jeffrey W. Schubert - Ambler PA, US
Nathan Kett - Columbia TN, US
Amy Zartman - Hatfield PA, US

International Classification:

C07D 213/69
C07D 401/10
A61K 31/4439
C07D 213/73
C07D 213/74
C07F 5/02
A61K 31/69
A61K 31/444
C07D 401/14
C07D 471/04
A61K 31/4725
A61K 31/4709
A61K 45/06
C07D 413/10
A61K 31/5377
A61K 31/4545
C07D 417/10
A61K 31/541
C07D 413/12
A61K 31/4418

US Classification:

424722, 546296, 514348, 5462734, 514338, 546 13, 514 64, 546258, 514334, 546256, 514333, 546113, 514300, 546261, 514335, 546144, 514307, 546173, 514314, 514221, 544131, 5142355, 5462754, 514341, 5462774, 514339, 546194, 514318, 544 582, 5142278, 5462757

Abstract:

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.